Wnt-1与Snail在结肠癌组织中的表达及其临床意义  

Clinical significance of expression of Wnt-1/Snail in colon cancer

作　　者：郭云霞[1] 王郁杰[1] 王瑞勤[1] 郭娜[1] 

机构地区：[1]郑州人民医院颐和医院消化内科,河南省郑州市450003

出　　处：《世界华人消化杂志》2014年第16期2370-2374,共5页World Chinese Journal of Digestology

基　　金：河南省卫生厅基金资助项目;No.2010004023~~

摘　　要：目的:探讨Wnt-1、Snail在结肠癌组织中的差异表达及其意义,并探讨两者与预后的影响关系.方法:选取79例结肠癌组织,应用免疫组织化学法检测Wnt-1、Snail蛋白的表达,分析其与临床病理分期之间的关系,并进行预后的关系分析.结果:79例结肠癌组织中Wnt-1与Snail的阳性率分别为46.8%、57.0%,Wnt-1、Snail的表达与结肠癌的分化程度、分期、淋巴转移有关(P<0.05),并呈现明显的正相关性(r=0.418,P<0.01).Kaplan-Meier法生存分析显示Wnt-1与Snail阳性组中位生存期明显低于阴性组中位生存期(30.00 mo±1.25 mo vs 44.00 mo±4.25 mo;30.00 mo±1.68 mo vs 57.00 mo±6.36mo,P<0.01).Cox回归表明肿瘤浸润深度、临床分期、淋巴结转移以及Wnt-1及Snail的异常表达是影响结肠癌患者预后的危险因素.结论:结肠癌患者可能存在Wnt-1、Snail异常表达,Wnt-1、Snail可作为结肠癌的一个预后指标.AIM： To investigate the expression of Wnt-1 and Snail in colon cancer, and to analyze their clinical significance. METHODS： The expression of Wnt-1 and Snail in 79 colon cancer tissues was detected by immunohistochemistry. The relationships of Wnt-1 and Snail expression with clinicopathologic factors and survival were evaluated. RESULTS： The positive rates of Wnt-1 and Snail in 79 colon cancer tissues were 46.8% and 57%, respectively. Wnt-1 and Snail expression was significantly correlated with tumor differentiation, lymph node metastasis, and TNM stage（P ＆lt; 0.05）. There was a positive correlation between Wnt-1 and Snail expression（r = 0.418, P ＆lt; 0.01）.Survival analysis by the Kaplan-Meier method showed that the median survival times of Wnt-1 and Snail positive patients were significantly lower than those of Wnt-1 and Snail negative patients, respectively（30.00 mo ± 1.25 mo νs 44.00 mo ± 4.25 mo, 30.00 mo ± 1.68 mo νs 57.00 mo ± 6.36 mo, P ＆lt; 0.01）. The Cox regression analysis showed that the depth of tumor invasion, clinical stage, lymph node metastasis and abnormal expression of Wnt-1 and Snail were risk factors for the prognosis of patients with colon cancer. CONCLUSION： Patients with colon cancer may have abnormal expression of Wnt-1 and Snail, which can be used as prognostic indicators of colon cancer.

关 键 词：WNT-1 SNAIL 结肠癌 免疫组织化学 预后 

分 类 号：R735.35[医药卫生—肿瘤]