中老年人群幽门螺杆菌感染检测与肠化、活动性炎症分析  

Detection of helicobacter pylori infection and analysis on intestinal metaplasia and active inflammation in middle and elderly persons

作　　者：李园[1] 王昌正[1] 吴本俨[1] 

机构地区：[1]解放军总医院南楼消化科,北京100853

出　　处：《中华保健医学杂志》2014年第3期197-198,共2页Chinese Journal of Health Care and Medicine

摘　　要：目的 检测中老年人群尤其是高龄老年人幽门螺杆菌感染情况,分析幽门螺杆菌感染对胃黏膜活动性炎症和肠化的影响。方法 对1944例50岁以上的受检者行13C-尿素呼气试验（13C-UBT）,其中140例受检者行胃镜和病理活检,HE染色观察胃活动性炎症、肠化情况。结果 中老年人群幽门螺杆菌感染率为28.6%。50-60岁组,61-70岁组,71-80岁组,〉80岁组幽门螺杆菌感染率分别为31.1%、26.0%、24.3%、21.8%。胃黏膜活动性炎症、肠化发生率在幽门螺杆菌阳性组明显高于幽门螺杆菌阴性组（P〈0.01）。结论 随年龄增长,幽门螺杆菌感染率呈下降趋势,高龄老年人尤为明显。幽门螺杆菌感染可导致胃黏膜活动性炎症和肠化发生率增加。Objective To investigate Helicobacter Pylori infections in middle and elderly persons and to analyze the effect of Hp infection on acute inflammation of gastric mucosa and intestinal metaplasia. Methods A total of 1944 over 50 years old subjects were examined with 13 C urea breath test. At the sametime, gastroscopy and histopathologic examination also were performed in 140 subjects. Results The infection rate was 28.6%o In respect of age distribution,50 - 60 years old group,61 - 70 years old group,71 - 80 years old group and over 80 years old group were 31.1%,26.0%,24.3%,21.8% respectively. Occurrence of acute inflammation and intestinal metaplasia were significantly higher in Hp positive group than in Hp negative group,P 〈 0.001. Conclusion Hp infection rate gradually reduced with age increase especially in very elderly persons. Hp infections would increase acute inflammation of gastric mucosa and intestinal metaplasia.

关 键 词：幽门螺杆菌感染 老年人 肠化 活动性炎症 

分 类 号：R573[医药卫生—消化系统]