P21基因rsi059234位点多态性与东北地区汉族女性子宫内膜癌发病风险相关性  

Relationship Between P21 Gene rs1059234 Polymorphisms and the Risk of Endometrial Cancer among Northeastern Han Women

作　　者：银铎[1] 王宁[1] 张淑兰[1] 姜艳[1] 鲁艳明[1] 魏恒[1] 霍乃晨[1] 肖倩[1] 欧阳玲[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004

出　　处：《医学临床研究》2014年第6期1041-1044,共4页Journal of Clinical Research

基　　金：国家自然科学基金（No.81202047）,辽宁省自然科学基金计划（No.201202265）

摘　　要：【目的】研究 p21基因 rs1059234位点多态性与东北地区汉族女性子宫内膜癌之间的相关性。【方法】通过测序及PCR-RFLP方法，对263例子宫内膜癌患者（观察组）及315例健康人群（对照组）的外周血DNA的 p21基因 rs1059234位点进行基因型分型，并分析分型与子宫内膜癌之间的相关性。【结果】观察组中 rs1059234位点C等位基因频率较对照组明显升高（P ＝0．039）。rs1059234位点 CC基因型频率在观察组中与对照组相比呈明显升高趋势（0．335vs 0．219，P＝0．045），CC基因型增加子宫内膜癌的风险（OR＝1．589，95％ CI：1．010～2．502），但是经回归分析校正后，CC 基因型并不增加子宫内膜癌的风险（OR＝1．623，95％ CI：0．720～3．659，P＝0．243）。【结论】在东北地区汉族女性中，p21基因 rs1059234位点的多态性与子宫内膜癌的发生风险无明显关联。[Objective]To explore the correlation between p21 gene rs1059234 polymorphisms and endome-trial cancer in Han women from northeast China.[Methods]The sequencing and PCR-restriction fragment length polymorphism（PCR-RFLP）were used for the genotyping of p21 gene rs1059234 in peripheral blood DNA of 263 patients with endometrial cancer（observation group）and 315 healthy subjects（control group）. The correlation between the genotypes and endometrial cancer was analyzed.[Results]Compared with control group,the C allele frequency of rs1059234 in observation group was increased obviously（P=0.039）,and the CC genotype frequency of rs1059234 in observation group had obvious increasing trend（0.335 vs.0.219,P=0.045）.The CC genotype could increase the risk of endometrial cancer（OR=1.589,95%CI：1.010～2.502）. After correction with regression analysis,the CC genotype didn＆#39;t increase the risk of endometrial cancer（OR=1.623,95% CI：0.720～3.659,P =0.243）.[Conclusion]Among Han women from northeast China,the rs1059234 polymorphism of p21 gene is not associated with the risk of endometrial cancer.

关 键 词：子宫内膜肿瘤 原癌基因蛋白质p21(ras) 多态现象 遗传 

分 类 号：R737.33[医药卫生—肿瘤]