血浆游离脂肪酸与缺血性心源性卒中的关系  

Relationship Between Plasma Free Fatty Acids and Ischemic Stroke Subtype

作　　者：樊冰倩 高小平[1] 

机构地区：[1]湖南省人民医院,湖南长沙410000

出　　处：《医学临床研究》2014年第6期1104-1106,共3页Journal of Clinical Research

摘　　要：【目的】探讨血浆游离脂肪酸（free fatty acids，FFA）与缺血性卒中亚型之间的关系【方法】收集湖南省人民医院2010年7月至2013年12月间收治的715例急性缺血性卒中患者入院时的一般临床资料，回顾性分析患者 FFA浓度与缺血性卒中各个亚型之间的关系。【结果】715例患者中，血清 FFA浓度在心源性（cardioembolic ，CE）卒中（1194．68±806．45 Eq/L）和非CE卒中组（793．73±611．87 Eq/L）之间相比较差异有显著性（P＜0．001）。所有合并心房颤动（AF）的卒中患者 FFA浓度（1297．48±818．48 Eq/L）明显高于无AF卒中患者（776．50±596．00 Eq/L），且两组相比较差异具有显著性（P＜0．01）；合并 AF 的 CE卒中患者的FFA浓度（1311．53±830．61 Eq/L）明显高于合并AF的非CE卒中患者（894．77±663．20 Eq/L），且差异亦具有显著性（P＜0．01）。【结论】急性缺血性卒中患者空腹血浆 FFA浓度与 CE卒中相关，FFA浓度升高，合并 AF可作为CE卒中的预测指标。[Obj ective]To explore the relationship between free fatty acids（FFA）and subtypes of ischemic stroke.[Methods]General clinical date of 715 patients with acute ischemic stroke on admission in Hunan pro-vincial people＆#39;s hospital from July 2010 to Dec.2013 were collected.The relationship between FFA concentra-tion and subtypes of ischemic stroke was analyzed retrospectively.[Results]Of 7 1 5 patients,there was signif-icant difference in serum FFA concentration between cardioembolic（CE）stroke and non-CE stroke（1194.68± 806.45Eq/L vs.793.73±611.87Eq/L）（P〈0.001）.FFA concentration in stroke patients with atrial fibrilla-tion（AF）was obviously higher than that in stroke patients without AF（1297.48±818.48Eq/L vs.776.50± 596.00Eq/L）,and there was significant difference between two groups（P 〈0.001）.FFA concentration in CE stroke patients with AF was obviously higher than that in non-CE stroke patients with AF（1311.53 ± 830.61Eq/L vs.894.77±663.20Eq/L）,and there was also significant difference between two groups（P〈0.001）.[Conclusion]Fasting FFA concentration in patients with acute ischemic stroke is associated with CE stroke.The increasing of FFA concentration and combination with AF can be used as predictive indicators of CE stroke .

关 键 词：卒中 脂肪酸类 血液 

分 类 号：R743.3[医药卫生—神经病学与精神病学]