焦脱镁叶绿酸-a的苯腙和氨基酸席夫碱的合成  

Synthesis of Phenylhydrazone and Amino acid Schiff Base of Pyropheophorbide-a

作　　者：杨晓英[1] 谭广慧[1,2] 曲凤玉[1,2] 金英学[1] 王进军[3] 

机构地区：[1]哈尔滨师范大学化学化工学院,哈尔滨50025 [2]哈尔滨师范大学生命科学技术学院,哈尔滨50025 [3]烟台大学化学化工学院,烟台264005

出　　处：《有机化学》2014年第6期1206-1211,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21272048;21171045);黑龙江省高效科技创新团队建设计划(No.2011TD010)资助项目~~

摘　　要：以焦脱镁叶绿酸-a甲酯为原料,通过E-环羰基分别与苯肼和氨基酸反应合成了焦脱镁叶绿酸-a甲酯苯腙和焦脱镁叶绿酸-a氨基酸席夫碱.苯腙的最大吸收波长显著红移.席夫碱最大吸收波长稍有蓝移,而其水溶性明显增大.所有新化合物的结构经1H NMR,MS或元素分析所证实.Methyl pyropheophorbide-a was used as starting material for the synthesis of phenylhydrazone and amino acid Schiff base by reactions of carbonyl group at 131-position. The maximum absorption wavelength of phenylhydrazone caused a red shift. The water-solubility of Schiff base was incremented, and the maximum absorption wavelength shifted hypsochromically. The structures of all these compounds were characterized by 1H NMR, MS and elemental analysis.

关 键 词：光动力治疗 焦脱镁叶绿酸-a甲酯(Mppa) 苯腙 氨基酸 席夫碱 水溶性 

分 类 号：O621.3[理学—有机化学]