经皮椎体成形术联合放疗治疗椎体骨转移癌疗效观察  

Investigation of effects of percutaneous vertebroplasty combined with radiotherapy for treatment of spinal vertebra metastases

作　　者：李迎春[1] 王卓敏[1] 任丽[2] 张文华[3] 张小玉[1] 余娟[1] 陈波[1] 

机构地区：[1]解放军第452医院核医学科,四川成都610021 [2]解放军第452医院放疗科,四川成都610021 [3]解放军第452医院放射科,四川成都610021

出　　处：《西部医学》2014年第7期894-895,898,共3页Medical Journal of West China

摘　　要：目的探讨经皮椎体成形术(PVP)联合放疗治疗椎体骨转移癌的临床疗效。方法将45例经病理确诊的恶性肿瘤椎体骨转移患者随机分为两组:放疗组23例,采用6MV X射线外照射,3Gy/次,5次/周,总剂量30Gy;联合组22例,首先采用经皮椎体成形术稳定椎体,随后给予局部放疗,方法同放疗组。采用VRS/NRS法对疼痛程度进行分级,评价疼痛缓解程度,采用ECOG体力状况评分标准评价行为状态改善情况。结果两组患者均按计划完成治疗,其中放疗组疼痛缓解率73.9%(17/23),行为状态改善率78.3%(18/23);联合组疼痛缓解率95.5%(21/22),行为状态改善率90.9%(20/22),两组间差异均有统计学意义(P<0.05)。结论经皮椎体成形术联合放疗治疗椎体骨转移癌较单独放疗疼痛缓解率明显增强,同时可提高患者的生活质量,具有临床推广应用价值。Objective To investigate the effects of percutaneous vertebroplasty（PVP）combined with radiotherapy for treatment of spinal vertebra metastases.Methods 45 patients with spinal vertebra metastases confirmed by pathology were randomly divided into radiotherapy group and combination group.The radiotherapy group（23 cases）was treated with radiotherapy of 6MV X-ray,3Gy/f,5f/week,DT 30Gy.The combination group（22 cases）was treated with PVP before radiotherapy with the same fraction and dose as radiotherapy group.Degree of pain-relief was evaluated with VRS/NRS method.The improvement of behavior was evaluated with ECOG physical status score.Results All cases were treated as planned.The pain-relief rate of radiotherapy group was 73.9%（17/23）,and behavior improvement rate was 78.3%（18/23）.The pain relief rate of combination group reached 95.5%（21/22）,and behavior improvement rate reached 90.9%（20/22）.Conclusion Treating patients of spinal vertebra metastases by combination of PVP and radiotherapy not only can improve the pain-relief rate,but also can enhance the life quality of patients.

关 键 词：椎体转移癌 放射治疗 椎体成形术 

分 类 号：R738.1[医药卫生—肿瘤]