碳酸酐酶Ⅸ、桩蛋白与生长抑素受体在十二指肠乳头癌组织中的表达及意义  

The expression and its significance of detecting carbonic anhydrase Ⅸ(CAⅨ),paxillin and somatostatin receptors(SSTR) in patients with duodenal carcinoma

作　　者：田琳[1] 杨虹 刘东杰[1] 胡立华[1] 张继晔[1] 

机构地区：[1]黑龙江省医院消化内科,黑龙江哈尔滨150036 [2]哈尔滨市红十字中心医院普内科,黑龙江哈尔滨150076

出　　处：《中国现代医生》2014年第20期34-36,共3页China Modern Doctor

摘　　要：目的探讨十二指肠乳头癌组织中碳酸酐酶Ⅸ(CAⅨ)、桩蛋白与生长抑素受体(SSTR)的表达及临床意义。方法应用免疫组化方法检测87例十二指肠乳头癌组织中碳酸酐酶Ⅸ(CAⅨ)、桩蛋白与生长抑素受体(SSTR)的表达。结果 87例十二指肠乳头癌中,CAⅨ阳性率达71.3%(62/87),桩蛋白阳性率达74.7%(65/87),显著高于其他两组(P<0.05)。而生长抑素受体阳性率48.2%(42/87),显著低于其他两组(P<0.05)。且低分化组的十二指肠乳头癌的CAⅨ阳性率、桩蛋白阳性率、SSTR阳性率与中、高分化组比较,差异显著(P<0.05)。而M1期的十二指肠乳头癌的CAⅨ阳性率、桩蛋白阳性率、SSTR阳性率与M0期比较,差异显著(P<0.05)。结论碳酸酐酶Ⅸ(CAⅨ)、生长抑素受体(SSTR)及桩蛋白三者与十二指肠乳头癌的发生、发展及转移密切相关,可以作为诊断早期肿瘤的重要指标之一,也可以用于评价肿瘤的发展及预后。Objective To investigate the expression and significance of detecting carbonic anhydrase Ⅸ（CA Ⅸ）, paxillin（paxillin） and somatostatin receptors（SSTR） in patients with duodenal carcinoma. Methods The immunohistochemistry was used to detect 87 cases of duodenal carcinoma carbonic anhydrase Ⅸ（CA Ⅸ）, paxillin（paxillin） and somatostatin receptors（SSTR） expression. Results Among 87 cases of duodenal cancer, CA Ⅸ positive rate of 71.3%（62/87）, paxillin positive rate of 74.7%（65/87）, was significantly higher than other groups（P〈0.05）. The rate of somatostatin receptor-positive rate of 48.2%（42/87）,was significantly lower than than other groups（P〈0.05）. And the positive rate of duodenal CA Ⅸ poorly differentiated cancer group, the positive rate of protein pile, SSTR-positive rate compared with the well-differentiated group（P0.05）. The positive rate of M1 CA Ⅸ of duodenal papilla cancer, the positive rate of paxillin, SSTR-positive rate compared with M0 stage（P〈0.05）. Conclusion Carbonic anhydrase Ⅸ（CAⅨ）, occurrence, development and metastasis of somatostatin receptor（SSTR） and paxillin and three closely related duodenal cancer, can serve as an important indicator of early diagnosis of cancer, can also be used to assess tumor development and prognosis.

关 键 词：十二指肠乳头癌 碳酸酐酶Ⅸ(CAⅨ) 桩蛋白 生长抑素受体(SSTR) 

分 类 号：R735.804[医药卫生—肿瘤]