原发胃非霍奇金淋巴瘤51例临床特点及治疗分析  

Clinical characteristics and treatment analysis of 51 cases of primary gastric non-Hodgkin lymphoma

作　　者：黄月华[1] 周道斌[1] 段明辉[1] 李剑[1] 庄俊玲[1] 韩冰[1] 张薇[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院血液内科,100730

出　　处：《白血病．淋巴瘤》2014年第6期339-342,共4页Journal of Leukemia & Lymphoma

基　　金：北京市自然科学基金（7122140）

摘　　要：目的 探讨原发胃非霍奇金淋巴瘤（PG-NHL）的临床特征、影响预后因素及手术治疗对预后的影响.方法 对2003年1月至2013年7月51例PG-NHL病例资料进行回顾性分析.结果 51例患者中男性26例,女性25例,男：女=1.04∶1.发病年龄18～80岁,中位发病年龄56岁.中位随访时间32个月（1～114个月）.1、3、5年总生存率分别为90.2％、82.4％、80.4％.手术＋化疗、单纯化疗和抗幽门螺旋杆菌（HP）治疗患者的无进展生存和总生存差异均无统计学意义（P值分别为0.192和0.174）.51例患者中,化疗后仅1例（2.0％）出现消化道出血、穿孔严重的消化道并发症.手术组6例（46.2％）患者术后出现不同程度的早饱、胃排空障碍、碱性反流性胃炎、倾倒综合征等并发症.结论 手术并不能提高PG-NHL患者生存,而且化疗组长期生存质量优于手术组.Objective To investigate the clinical characteristics and prognostic factors in patients with primary gastric non-Hodgkin lymphoma （PG-NHL）.Methods The pathological data of 51 PG-NHL patients admitted in our hospital from 2003 to 2013 were analyzed retrospectively.Results In 51 patients with PG-NHL,there were 26 males and 25 females.The patients＇ age ranged from 18 to 80 years old with median age as 56 years old.The median survival time was 32 months （range from 1 to 114 months）.The oneyear overall survival （OS）,three-year OS and five-year OS were 90.2 %,82.4 % and 80.4 %,respectively.The surgery did not significantly improve PG-NHL patients＇ progress free survival and OS.Only 1 （2.0 %） patient had gastrointestinal hemorrhage and perforation after chemotherapy.However,6 （46.2 %） patients suffered from early satiety,gastric emptying disorder,alkaline reflux gastritis and dumping syndrome in surgery group.Conclusions Surgery did not improve the survival of PG-NHL patients.The life quality in chemotherapygroup is better than that in surgical group.

关 键 词：肿瘤 原发性 胃肿瘤 淋巴瘤 非霍奇金 预后 无进展生存 总生存 

分 类 号：R735.2[医药卫生—肿瘤]