乙型肝炎病毒标志物及血清生化指标与原发性肝细胞癌的关系分析  

Analysis on the relationship between hepatitis B virus markers,serum biochemical indexes and primary hepatocellular carcinoma

作　　者：王效军[1] 徐秀娟[1] 倪进东[1] 熊咏珍[2] 李涛[3] 

机构地区：[1]广东医学院公共卫生学院,广东东莞523808 [2]广东医学院东莞校区门诊部 [3]广东医学院基础医学院

出　　处：《实用预防医学》2014年第7期782-783,787,共3页Practical Preventive Medicine

基　　金：湛江市科技攻关计划项目(2012C3103009)

摘　　要：目的探讨原发性肝细胞癌患者中乙型肝炎病毒标志物和血清生化指标的分布状况及其与原发性肝细胞癌的关系,为原发性肝细胞癌的防治提供依据。方法测定原发性肝癌患者血清HBsAg、HBeAg、HBeAb、HBcAb等病毒标志及血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)等生化指标,以病毒标志的不同感染模式作为阳性分组依据,并与对照组比较,分析血清生化指标的分布状况及其与原发性肝细胞癌的关系。结果 217例原发性肝细胞癌患者中HBsAg阳性者165例(76.0%),HBsAg及HBeAg双阳性者44例(20.3%),"大三阳"者为55例(25.3%),"小三阳"者为87例(40.1%);在"大三阳"、"小三阳"感染组与对照组的比较中AST和ALT差异有统计学意义(P<0.001)。结论乙型肝炎病毒的感染会引起原发性肝细胞癌患者肝脏炎症损害,应同等重视"大三阳"与"小三阳"患者的抗病毒治疗,以利于原发性肝细胞癌的防治。Objective To explore the distribution of hepatitis B virus markers and serum biochemical indexes in patients with primary hepatocellular carcinoma （PHC） and the relationship between the above- mentioned markers, indexes and PHC, and to provide evidence for prevention and control of PHC. Methods HBV markers （HBsAg, HBeAg, HBeAb and HBcAb） and se- rum biochemical indexes （AST,ALT, ALT, ALB and TBIL） of PHC patients were detected. HBV- positive patients were subgrouped according to different infection modes of HBV markers, and then a comparison was conducted between the subgroups and control group. The distribution of serum biochemical indexes and the relationship between the indexes and PHC were analyzed. Re- suits Among 217 patients with PHC, 165 （76.0%） were HKsAg positive, 44 （20.3 % ）HBsAg ＋ HBeAg pasitive, 55 （25.3 % ） HBsAg ＋ HBeAg ＋ HBcAb positive and 87 （40.1% ） HBsAg ＋ HBeAb ＋ HBcAb positive. The serum levels of AST and ALT were higher in HBsAg ＋ HBeAg ＋ HBcAb positive group and HBsAg＋ HBeAb ＋ HBcAb positive group than in the control group, with statistically significant difference （P 〈 0. 001 ）. Conclusions The infection of hepatitis B virus may cause damage and inflammation in livers of patients with PHC. Antiviral treatment should be implemented equally in patients with HBsAg ＋ HBeAg ＋ HBcAb positive or HBsAg ＋ HBeAb ＋ HBcAb positive so as to facilitate PHC prevention and therapy.

关 键 词：原发性肝细胞癌 乙型肝炎病毒 标志物 危险因素 

分 类 号：R735.7[医药卫生—肿瘤]