轴突转运障碍与阿尔茨海默病  

Axonal Transport and Alzheimer's Disease

作　　者：戴甲培[1,2] 王燕子[1,2] 

机构地区：[1]中南民族大学武汉神经科学与神经工程研究所,武汉430074 [2]中南民族大学生命科学学院,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2014年第2期36-40,共5页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金面上资助项目(31070961);中南民族大学重点科研机构基金资助项目(XJS9001;CJS13001)

摘　　要：指出了一个神经元依靠其特有的分支与其他神经元形成连接并构成功能回路,确保神经信号的传递和实现神经功能,轴突转运对确保神经元的结构和功能非常重要.研究表明:微管、分子马达和其他辅助因子的协调和整合为轴突转运功能的实现提供了重要的分子基础.大量研究发现:轴突转运功能障碍与阿尔茨海默病的起因和进展有重要的关系,简要综述了目前研究进展,对轴突转运障碍与阿尔茨海默病发病之间的关系进行了阐述.A neuron has the unique branch structure that can connect with other neurons to build up the functional neural circuits to ensure the neural signal transmission and the other neural functions. Axonal transport is very important to maintain the structure and function of a neuron. Previous researches have demonstrated that the coordination and integration of microtubules, molecular motors and other associated factors provided the important molecular bases for axonal transport. A large number of studies have suggested that axonal transport deficits are related to the cause and development of Alzheimer＇s disease. This paper briefly reviewed the current research progress in this area and explained the relationship between axonal transport deficits and Alzheimer＇s disease.

关 键 词：阿尔茨海默病 轴突转运障碍 轴突漏 分子马达 

分 类 号：R741.02[医药卫生—神经病学与精神病学] Q2[医药卫生—临床医学]