新生儿脐血乳酸与心肌酶的关系  

Relationship between neonatal cord blood lactate and myocardial enzymes

作　　者：陈海天[1] 袁媛[1] 王广涵[1] 袁茜[2] 杨莹[2] 黄娜娅 王子莲[1] 

机构地区：[1]中山大学附属第一医院妇产科,广州510080 [2]中山大学中山医学院

出　　处：《中华临床医师杂志（电子版）》2014年第13期51-53,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的：通过测定新生儿脐血中肌酸激酶（CK）、肌酸激酶同工酶MB（CK-MB）和脑钠肽（BNP）的水平，结合脐血乳酸的结果，研究新生儿脐血乳酸与心肌酶的关系。方法收集2009年7-12月在中山大学附属第一医院产房分娩的新生儿65例，分别测定脐动静血的pH值、剩余碱等指标及脐静脉血乳酸、BNP和心肌酶（CK-MB、CK），并对上述指标进行相关性分析。结果血乳酸水平与血气分析各项指标具有密切的统计学负相关性。脐动脉血气分析结果与心肌酶及BNP无明显统计学关联，血乳酸水平与CK-MB具有统计学正相关性，而与CK及BNP并无统计学关联性。结论乳酸与血气分析指标中的pH值、剩余碱有密切的关联性，可以在缺氧早期即反映出机体的酸碱平衡状态，而相较于血气分析，更能够特异性地衡量由于代谢性酸中毒造成的心肌损伤情况，与CK-MB线性相关，可作为判断心肌损伤发生、预测严重程度的指标。ObjectiveTo explore the relationship between neonatal cord blood lactate and myocardial enzymes. MethodsThis study recruited 65 neonates delivered in our hospital from July 2009 to December 2009. To detect their cord blood CK/CK-MB/BNP and cord blood lactate, pH and BE. To statistics them by correlation.ResultsCord blood lactate was negatively correlated with many markers in blood gas analysis. No significant difference was found in umbilical artery blood gas result and any of the myocardial enzymes. Cord blood lactate was positively correlated with cord blood CK-MB, however, not correlated with cord blood CK and BNP.ConclusionsCord blood lactate could reflect body’s acid-base balance situation in early phase of hypoxia. And it is more specific than blood gas analysis in judgment of myocardial Injury. Cord blood lactate was positively correlated with cord blood CK-MB, so it might predict the severity of myocardial injury, as a useful marker.

关 键 词：肌酸激酶 利钠肽 脑 乳酸 心肌损伤 肌酸激酶同工酶 

分 类 号：R722.1[医药卫生—儿科]