阿尔茨海默病的相关免疫机制及治疗研究进展  

Immune-related mechanisms and treatment of Alzheimer's disease

作　　者：朱丹[1] 纪超[1] 左萍萍[1] 

机构地区：[1]中国医学科学院基础医学研究所药理室,北京100005

出　　处：《中华脑科疾病与康复杂志（电子版）》2014年第3期34-37,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：国家自然科学基金(81100801)

摘　　要：阿尔茨海默病(AD)是最常见的老年神经退行性疾病之一。研究发现,免疫系统的功能状态与AD的发病密切相关,而其中炎症反应及促炎细胞因子起着关键性的作用。AD患者脑内可见小胶质细胞与星形胶质细胞的活化,其活化可产生神经保护作用,但诱发致炎因子分泌过度反而加剧了疾病的进程。Alzheimer＇s disease （AD）is the most common neurodegenerative disease in elderly. Previous study found that the onset of AD was closely associated with the functional status of the immune system,in which inflammation and proinflammatory cytokines play key roles. Microglia and astrocyte are activated in the brain of AD patients. In addition of neuroprotcctive effect produced after activation of microglia and astrocyte, proinflammatory cytokines excessive release could also been found, which probably exacerbated the disease process.

关 键 词：阿尔茨海默病 炎症 小神经胶质细胞 星形细胞 免疫疗法 

分 类 号：R749.16[医药卫生—神经病学与精神病学]