颅内动脉瘤破裂介入术后应用西洛他唑对IL-6及MDA的影响  

Influence of Cilostazol on Interleukin-6 and Malondialdehyde after Treatment of Intracranial Aneurysm Ruptured by Interventional Therapy

作　　者：张宗银[1] 张紫寅[1,2] 唐建建[1,2] 罗安志 龙鸿川 黄志敏[1] 吴云[1] 王敏[1] 

机构地区：[1]眉山市人民医院神经外科,四川眉山620010 [2]海南医学院附属医院神经外科,海口570102

出　　处：《临床误诊误治》2014年第7期104-106,共3页Clinical Misdiagnosis & Mistherapy

摘　　要：目的探讨颅内动脉瘤(intracranial aneurysm,IA)破裂介入术后应用西洛他唑对白细胞介素-6(IL-6)及丙二醛(MDA)的影响。方法选取2009年5月—2012年10月海南医学院附属医院100例IA破裂行介入治疗患者,按术后是否服用西洛他唑分为观察组32例和对照组68例。观察比较入院时及血管内治疗第10、20、30天两组血清IL-6及MDA水平。结果观察组血清IL-6、MDA约术后20 d逐渐下降至正常水平,且下降速度远大于对照组(t=7.05,P<0.05;t=6.12,P<0.05)。结论 IA破裂介入治疗术后服用西洛他唑能有效降低全身炎症及应激反应,但其预防动脉瘤发生、再次破裂及复发的效果仍有待进一步验证。Objective To explore the influence of Cilostazol on interleukin-6 （IL-6） and malondialdehyde （MDA） af-ter treatment of intracranial aneurysm （IA） ruptured by interventional therapy. Methods A total of 100 IA aneurysm ruptured patients undergoing interventional therapy during May 2009 and October 2012 were divided into Cilostazol treatment group （treatment group, n =32） and non-Cilostazol treatment group （control group, n =68）. The levels of serum IL-6 and MDA in the two groups were compared on the admission day, 10th d, 20th d and 30th d after intravascular therapy. Results The levels of serum IL-6 and MDA in treatment group gradually decreased to normal 20th d after operation, and the decreased rate in treatment group was significantly higher than that in control group （t =7. 05, P 〈0. 05; t =6. 12, P 〈 0. 05）. Conclusion Cilostazol medication after treatment of IA ruptured by interventional therapy may effectively reduce the incidence rates of systemic inflammation and stress response, but the effect of prevention of aneurysm ruptured recurrence needs to be further studied.

关 键 词：颅内动脉瘤 动脉瘤 破裂 白细胞介素-6 丙二醛 并发症 血管痉挛 颅内 

分 类 号：R739.41[医药卫生—肿瘤]