AD患者血浆淀粉样变程度、血清总胆固醇水平、全血黏度变化及其相关性  

Plasma amyloidosis degree,total cholesterol level and whole blood viscosity changes and their correlations in AD patients

作　　者：兰杰[1] 李晓亮[1] 薛蓉[2] 李春芳[2] 宋敬敬[1] 孙续国[1] 

机构地区：[1]天津医科大学,天津300203 [2]天津医科大学总医院

出　　处：《山东医药》2014年第27期11-13,17,共4页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30973157)

摘　　要：目的观察阿尔茨海默病(AD)患者血浆淀粉样变程度、血清总胆固醇水平及全血黏度变化,并分析其相关性。方法 AD患者30例(观察组),健康对照人群30例(对照组),采用FL F-2500荧光分光光度计检测淀粉样纤维荧光强度,计算淀粉样纤维水平;LBY-N6A血流变仪检测血液流变学指标;TBA-120FR全自动生化仪检测血脂。多元线性回归分析法分析血浆淀粉样变程度、全血黏度(高切)、血清总胆固醇间的关系。结果观察组及对照组血浆淀粉样纤维水平分别为(16.63±5.67)、(12.83±0.27)U/mL,血清总胆固醇水平分别为(4.71±1.24)、(3.95±0.22)mmol/L,全血黏度(高切)水平分别为(4.16±0.54)、(3.74±0.15)mPa·s,两组比较,P均<0.05。多元线性回归分析显示,血浆淀粉样变程度、血清总胆固醇水平与全血黏度(高切)呈正相关趋势(r分别为0.598、0.664,P均<0.05)。结论 AD患者血浆淀粉样变程度、血清总胆固醇水平、全血黏度升高,前两者与后者呈正相关。Objective To observe the plasma amyloidosis degree , serum total cholesterol level and whole blood vis-cosity changes in patients with Alzheimer＆#39;s disease （ AD） , and to analyze their correlations .Methods Thirty cases of AD patients （observation group） and 30 cases of healthy controls （control group） were selected.The plasma amyloid fibril flu-orescence intensity was detected by FL F-2500 fluorospectro photometer , then we calculated the amyloid fibril levels;LBY-N6A rheology instrument was used to examine the hemorrheological parameters;and TBA-120FR automatic biochemical an-alyzer was used to test the blood lipid level .Multivariate linear regression analysis was used to analyze the relationships a-mong plasma amyloidosis degree , whole blood viscosity （ high shear part ） and serum total cholesterol .Results In the ob-servation group and control group , the plasma amyloid fibril levels were （16.63 ±5.67） and （12.83 ±0.27） U/mL, re-spectively;the whole blood viscosity （high） were （4.16 ±0.54） and （3.74 ±0.15） mPa＆#183; s, respectively;and the total cholesterol levels were （4.71 ±1.24） and （3.95 ±0.22） mmol/L, respectively （all P＆lt;0.05）.The multivariate linear regression analysis showed whole blood viscosity （ high shear part ） was positively correlated with plasma amyloidosis degree and serum total cholesterol level （r=0.598, 0.664;all P＆lt;0.05）.Conclusion Plasma amyloidosis degree, serum total cholesterol level and whole blood viscosity increase in AD patients , and the first two are positively correlated with the latter one.

关 键 词：阿尔茨海默病 血浆淀粉样变 血液流变学 血液黏度 

分 类 号：R741.05[医药卫生—神经病学与精神病学]