TGF-β1和HSP-47在翼状胬肉中的表达及其意义  

TGF-β1 and HSP-47 expression in pterygium

作　　者：阎慧[1] 盘如刚[1] 姚莎莎[1] 杨志蓉[1] 

机构地区：[1]中国四川省雅安市人民医院眼科,625000

出　　处：《国际眼科杂志》2014年第7期1203-1205,共3页International Eye Science

摘　　要：目的:研究转化生长因子β1(transforming growth factor-β1,TGF-β1)和热休克蛋白47(heat shock protein 47,HSP-47)在翼状胬肉和正常结膜组织表达的差异,从而探讨它们在翼状胬肉发生、发展中的作用,为翼状胬肉的治疗提供新的方向。方法:采用免疫组化方法比较翼状胬肉和正常结膜组织中TGF-β1和HSP-47的表达差异。结果:TGF-β1在翼状胬肉的鳞状上皮细胞中的表达水平明显高于正常结膜组织,在其基质层和内皮层有中等量表达,同时,在翼状胬肉纤维层的炎性细胞和血管内皮细胞中TGF-β1也有明显表达。与此相反,在正常结膜组织中TGF-β1表达较弱。HSP-47在翼状胬肉的固有层高表达,在上皮细胞表达较弱,在正常结膜组织中则未见明显表达。结论:相比正常结膜组织,TGF-β1和HSP-47均在翼状胬肉组织中有较高水平的表达,因此推测二者在诱导翼状胬肉的发生、发展中起着重要的作用。AIM ：To investigate the expression transforming growth factor-β14 （TGF-β1） and heat shock protein 47 （HSP-47）, in pterygium and normal conjunctiva tissues, in order to study the roles of these cytokines played in the pathogenesis in human pterygium. METHODS：The expression difference of TGF-β1, HSP- 47 between human pterygium and normal conjunctive tissues were compared by immuno- histochemistry technique. RESULTS：The positive expression of TGF-β1, HSP-47 was stronger than in normal conjunctive tissues （P 〈 0.05）, the TGF-β1 expressed in all layers of pterygium, especially in the squamous epithelium, in the inflammation cells and vascular endothelial cells also expressed. The HSP-47 showed higher expressed in the lamina propria layer of pterygium, and weakly expressed in epithelial layer, no obvious expression in normal conjunctive tissues. CONCLUSION ：Over-expression of TGF-β1 and HSP-47 in pterygium compared to the normal conjunctiva tissues may play a critical role during the occurrence, deveIOPment and invasion of the ptervgium.

关 键 词：翼状胬肉 转化生长因子Β1 热休克蛋白47 

分 类 号：R777.33[医药卫生—眼科]