MTA1在非小细胞肺癌组织中的表达及意义  

Expression and significance of MTA1 in non-small cell lung cancer

作　　者：徐彩华[1] 沈振亚[1] 黄皓岳[1] 叶文学[1] 余云生[1] 陈亦江[2] 

机构地区：[1]苏州大学第一附属医院心血管外科,江苏省215006 [2]南京医科大学第一附属医院胸心外科

出　　处：《江苏医药》2014年第13期1530-1532,F0002,共4页Jiangsu Medical Journal

摘　　要：目的探讨转移相关蛋白1(MTA1)在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法采用实时荧光定量PCR技术和免疫组织化学法检测97例NSCLC组织(A组)及其相应癌旁组织(B组)MTA1的表达。结果 A组MTA1mRNA及蛋白表达水平均高于B组(P<0.01),腺癌MTA1的表达高于鳞癌(P<0.01),MTA1的表达与NSCLC的淋巴结转移相关(P<0.01)。结论 MTA1在NSCLC组织中表达上调,可能参与了NSCLC的发生发展及转移。Objective To study the expression and significance of metastasis-associated protein1（MTA1） in non-small cell lung cancer（NSCLC）.Methods Real-time PCR and immunohistochemistry assay were performed to detect the expression of MTA1in 97 NSCLC specimens（group A）and tumor-adjacent specimens（group B）.Results MTA1expression was significantly higher in group A than that in group B（P〈0.01）,which was higher in adenocarcinoma than that in squamous carcinoma（P〈0.01）.MTA1expression in group A was higher with lymphatic metastasis than that without（P〈0.01）.Conclusion MTA1is overexpressed in NSCLC and may participate in the occurrence,development and metastasis of NSCLC.

关 键 词：非小细胞肺癌 转移相关蛋白1 

分 类 号：R734[医药卫生—肿瘤]