影响胃癌患者预后的相关因素分析  

An analysis of factors influencing prognosis of patients with gastric carcinoma

作　　者：蒋继文[1] 戎亚雄[1] 陈飞 单国平[1] 

机构地区：[1]江苏大学附属武进医院普通外科,213002

出　　处：《江苏医药》2014年第13期1542-1545,共4页Jiangsu Medical Journal

摘　　要：目的探讨影响胃癌患者预后的相关因素。方法回顾性分析352例胃癌患者的临床及病理资料,评估总生存期和生存率,Cox回归模型分析相关因素与预后的关系。结果总生存期为1.7-71个月,中位生存期60个月,死亡121例,1、3、5年生存率分别是89%、63%、51%。患者性别与胃癌预后无关(P>0.05),而年龄、肿瘤直径、浸润深度、组织学类型、TNM分期、pN分期、淋巴结转移率(MLR)、糖链抗原199和癌胚抗原(CEA)均与胃癌预后相关(P<0.05);其中,年龄、TNM分期、pN分期、MLR和CEA是影响胃癌预后的主要因素(P<0.05)。结论年龄、TNM分期、pN分期、MLR和CEA与胃癌预后密切相关。Objective To analyze the factors influencing prognosis of patients with gastric carcinoma.Methods Clinical data of 352 patients with gastric carcinoma were retrospectively analyzed.The overall survival duration and survival rate were calculated.The factors influencing the prognosis were analyzed by Cox regression model.Results Overall survival time was ranged from 1.7months to 71months with a median survival time of 60months.Survival rates of 1-year,3-year,and5-year were 89%,63%and 51%,respectively.Gender had no correlation with the prognosis of gastric cancer（P〉0.05）.The factors of age,diameter of tumor,depth of invasion,histological type,TNM stage,pN stage,metastasis lymph nodes ratio（MLR）,carbohydrate antigen 199and carcino-embryonic antigen（CEA）were closely correlated with the prognosis of gastric cancer（P〈0.05）,of which the age,TNM stage,pN stage,MLR and CEA were the main factors influencing the prognosis（P〈0.05）.Conclusion The age,TNM stage,pN stage,MLR and CEA are closely correlated with the prognosis in the patients with gastric cancer.

关 键 词：胃癌 预后 

分 类 号：R735[医药卫生—肿瘤]