艾迪注射液对食管癌VEGF表达和MVD的影响  

Effect of Aidi injection on VEGF expression and MVD in esophageal cancer

作　　者：施庆彤[1,2] 吴鸿雁[3] 曹彬[2] 

机构地区：[1]南京中医药大学,江苏省210046 [2]南京鼓楼医院心胸外科 [3]南京鼓楼医院病理科

出　　处：《江苏医药》2014年第13期1545-1547,共3页Jiangsu Medical Journal

摘　　要：目的探讨艾迪注射液对食管癌血管生成作用的影响。方法 66例经内镜活检证实为食管癌的患者随机分为两组:治疗组34例,术前给予艾迪注射液治疗5d;对照组32例,术前不用药物治疗。应用免疫组化SP法检测肿瘤标本中的血管内皮细胞生长因子(VEGF)表达和肿瘤微血管密度(MVD),应用双抗体夹心ELISA法检测治疗前后血清VEGF的水平。结果治疗后,治疗组VEGF蛋白表达和MVD均低于对照组[(10407.86±914.13vs.11064.69±821.38)和(43.68±6.65vs.50.11±5.89)](P<0.05)。治疗后,治疗组血清VEGF低于对照组[(430.73±55.14)pg/ml vs.(471.59±62.09)pg/ml](P<0.05)。MVD和VEGF的表达呈正相关(r=0.947,P<0.01)。结论应用艾迪注射液可抑制食管癌的复发和转移。Objective To investigate the effect of Aidi injection on esophageal cancer angiogenesis.Methods Forty-six patients with esophageal cancer confirmed by endoscopic biopsy were randomly divided into two groups of A（treated with Aidi injection for 5days,34cases）and B（treated without drugs as control,32cases）.Immunohistochemical SP staining was used for detecting the expression of vascular endothelial growth factor（VEGF）and microvessel density（MVD）in cancer tissues.Serum level of VEGF was determined by double antibody sandwich ELISA before and after treatment.Results The expression of VEGF and MVD in cancer tissues after treatment were lower in group A than thoae in group B[（10407.86±914.13vs.11064.69±821.38）and（43.68±6.65vs.50.11±5.89）]（P〈0.05）.So did serum level of VEGF[（430.73±55.14）pg/ml vs.（471.59±62.09）pg/ml]（P〈0.05）.MVD was positively correlated to the expression of VEGF（r=0.947,P〈0.01）.Conclusion The treatment of patients with esophageal cancer with Aidi injection can inhibit tumor recurrence and metastasis.

关 键 词：食管癌 艾迪注射液 血管内皮细胞生长因子 肿瘤微血管密度 

分 类 号：R735[医药卫生—肿瘤]