小牛血去蛋白眼用凝胶治疗角膜上皮缺损的临床观察  

Clinical research of protein-free calf blood extract eye gel for corneal epithelial defect

作　　者：牛晓霞[1] 李云峰[1] 战露阳 

机构地区：[1]哈尔滨爱尔眼科医院,中国黑龙江省哈尔滨市150076

出　　处：《国际眼科杂志》2014年第7期1313-1315,共3页International Eye Science

摘　　要：目的:评价200g/L小牛血去蛋白眼用凝胶治疗持续性角膜上皮缺损的临床疗效。方法:观察持续性角膜上皮缺损患者168例(包括单疱病毒性角膜炎上皮型58例;化学烧伤24例;胬肉手术术后86例),随机分成小牛血去蛋白眼用凝胶组(84例),碱性成纤维细胞生长因子眼用凝胶组(bFGF,84例)。两组均滴眼4次/d,共7d。观察上皮缺损修复和患眼局部症状、体征等指标。结果:小牛血去蛋白眼用凝胶组和bFGF组疗效判断指标较治疗前皆有显著性差异(P<0.01)。小牛血去蛋白眼用凝胶组有效率(83.3%)高于bFGF组(69%);治疗单疱病毒性角膜炎上皮型角膜炎、化学烧伤和手术所引起的有效率分别为72.4%,69.2%和95.2%;观察过程中未见局部刺激和全身不良反应。结论:小牛血去蛋白眼用凝胶治疗持续性角膜上皮缺损疗效确切,安全性高。AIM： To evaluate the clinical effect of 200g/L protein- free calf blood extract eye gel for corneal epithelial defect. METHODS： One hundred and sixty-eight cases of corneal epithelial defect （58 cases with herpes simplex keratitis; 24 cases with chemical injury; 85 cases with pterygium operation injury） were randomly divided into two groups： 84 eyes were treated with protein-free calf blood extract eye gel; 84 cases were treated with basic fibroblast growth factor eye gel （bFGF）. The bFGF and protein-free calf blood extract eye gels were used 4 times a day. The treatment course was 7d. Epithelial defect restoration, local symptom and sign were observed. RESULTS： The difference between pre-treatment and post-treatment was significant （P〈 0. 01 ） in the two groups. The effect of protein-free calf blood extract eye gel （83.3%） group was prior to that of bFGF （69%） for corneal epithelial defect. The effective rate of protein-free calf blood extract eye gel in the herpes simplex keratitis, chemical injury and pterygium operation injury was 72.4% ,69.2% and 95.2%. Localized stimulus and adverse reaction of all over the body were not been observed. CONCLUSION： Protein-free calf blood extract eye gels is valuable and safe for corneal epithelial defect.

关 键 词：小牛血去蛋白眼用凝胶 碱性成纤维细胞生长因子眼用凝胶 角膜上皮缺损 

分 类 号：R772.2[医药卫生—眼科]