A型肉毒毒素治疗眼睑痉挛的临床研究  

Clinical study on botulinum toxin A injections for blepharospasm

作　　者：焦永红[1] 王乙迪[1] 潘哲[1] 

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室,中国北京市100730

出　　处：《国际眼科杂志》2014年第7期1350-1351,共2页International Eye Science

摘　　要：目的：探讨 A 型肉毒毒素治疗中重度眼睑痉挛的临床疗效。 方法：选取本院眼科门诊诊断明确的眼睑痉挛的患者113例,采用A型肉毒毒素局部注射治疗,并对治疗疗效进行评估。 结果：患者59例（52.2%）症状完全缓解,49例（43.4%）明显改善,4例（3.5%）部分改善,1例无效（0.9%）,总有效率达到99.1%。起效时间1~14d,大多于14d内达到最佳效果,疗效持续1~9 mo。不良反应可出现轻度眼睑闭合不全、上睑下垂、局部皮下瘀血等共23例,均在2~4 wk内恢复。 结论：局部注射A型肉毒毒素治疗中重度眼睑痉挛安全、有效。AIM ： To observe the efficacy of using botulinum toxin A in the treatment of blepharospasm. METHODS： Totally 113 patients with blepharospasm were managed with a local injection of botulinum toxin A, and the therapeutic effect was evaluated. RESULTS： Fifty-nine cases （52.2%） had a complete remission of symptoms, 49 patients （43.4%） presented with obvious relieved spasm, 4 cases （3. 5%） were partially relieved and the 1 patient （0. 9%） remained unchanged. The total effective rate was 99.1%. The time of beginning effect was 1 -14d. The recover time was mostly in 14d. The average of therapeutic effect lasted 1- 9mo. Adverse reactions such as mild palpebra dysraphism, palpebra ptosis and local subcutaneous blood stasis were found in 23 patients, and the symptoms disappeared in 2-4wk. CONCLUSlON：Botulinum toxin A can effectively control medium and severe blepharospasm by injecting a little dose on local muscle.

关 键 词：A型肉毒毒素 局部注射 眼睑痉挛 

分 类 号：R777.1[医药卫生—眼科]