γδT细胞对自身免疫性葡萄膜炎调节作用的研究进展  

Regulatory effect of γδT cells on the development of autoimmune uveitis

作　　者：唐凯[1] 崔彦[2] 毕宏生[2] 

机构地区：[1]山东中医药大学,济南250002 [2]山东中医药大学眼科研究所 山东中医药大学附属眼科医院,济南250002

出　　处：《中华实验眼科杂志》2014年第7期664-668,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（81072961、81100658）;山东省中医药科技发展计划项目（2013ZDZK-083）

摘　　要：γδT细胞占人外周血T淋巴细胞的1％ ～ 10％,能产生不同种类的细胞因子和趋化因子,发挥细胞毒效应,能以主要组织相容性复合体（MHC）非限制性方式直接识别并结合抗原,作为抗原递呈细胞增强效应T细胞的活性,进而促进自身免疫反应,具有连接天然免疫和获得性免疫的桥梁作用.研究认为,γδT细胞在葡萄膜炎发病中具有致病和保护的双向作用,其功能的复杂性及其对葡萄膜炎的调节作用日渐受到重视.目前,γδT细胞与αβT细胞、白细胞介素-17（IL-17）、调节性T细胞（Treg）、树突状细胞（DC）及Toll样受体（TLR）之间的相互作用对实验性自身免疫性葡萄膜炎（EAU）的影响和调节以及γδT细胞在葡萄膜炎中的临床应用现状已有较多的研究,就γδT细胞的生物学特点及其对葡萄膜炎的相关免疫调节机制进行综述.γδT cells account for approximately 1％-10％ of T lymphocytes in peripheral blood,but they are more abundant in mucosal tissue.γδT cells can produce a diverse range of cytokines to exert cytotoxic effector function.In addition,γδT cells can act as antigen-presenting cell（APC） to enhance the activity of effector T cells and contribute to autoimmunity.Based on the recognized ligands and their common lack of major histocompatibility （MHC） restriction,γδT cells are considered as nontraditional T cells that link innate and adaptive immunity.Previous studies showed that γδT cells have dual function.They can help to strengthen an immune process,and they might also help to suppress immune response.Up to now,many researches have focused on how γδT cells to impact and regulate the experimental autoimmune uveitis by the interaction between γδT cells with αβT cells,interleukine-17 （IL-17）,regulatory T cell （Treg）,dendritic cell（DC） and toll-like receptor（TLR）.In uveitis,a further understanding of the plasticity of γδT cells is required to specifically identify strategies for intentional modulation of their beneficial or detrimental regulatory activity.Here,the basic biological characteristics and the current knowledge on the regulation mechanism of γδT cells in uveitis disease were reviewed.

关 键 词：ΓΔT细胞 调节作用 葡萄膜炎 自身免疫 

分 类 号：R773.9[医药卫生—眼科]