血小板反应蛋白在眼部的研究进展  

Current research of thrombospondin in eye

作　　者：田润[1] 梅妍[1] 

机构地区：[1]云南省第一人民医院眼科,昆明650032

出　　处：《中华实验眼科杂志》2014年第7期669-672,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：云南省应用基础研究项目（2011FZ273）

摘　　要：血小板反应蛋白（TSP）由5个具有同源性的成员组成,其在全身不同组织细胞中的表达广泛,且具有复杂的生物学功能.TSP在眼组织中的分布也较为广泛,主要分布于视网膜色素上皮（RPE）细胞、角膜内皮细胞和晶状体上皮细胞等,也可由小梁网细胞所分泌,从而发挥不同作用.作为细胞因子,TSP在眼的病理生理过程中具有重要的调节作用,参与年龄相关性黄斑变性的发生、角膜疾病的修复、白内障的形成、开角型青光眼的发病与进展、眼部肿瘤的病理过程、增生性玻璃体视网膜病变和糖尿病视网膜病变等的病理过程.对TSP功能的研究有助于揭示眼科多种疾病的发病机制,并为相关病变的防治提供新的思路.就TSP在眼部的分布、眼部合成细胞及其在眼科相关疾病中作用的研究进展进行综述.Thrombospondin（TSP） has five members with diversiform expressions and complicated biologic functions in different histiocytes all over the body.TSP also is widely expressed in different parts of eye,such as retinal pigment epithelial cells,corneal endothelial cells and lens epithelial cells,etc.,and sometimes TSP is secreted by trabecular meshwork cells.As a group of cytokines,TSP plays an important regulating role in the physiological and pathological activities of eye.Studies determined that TSP participates in the pathogenesis of age-related macular degeneration,repaired of corneal diseases,formation of cataract,development of open-angle glaucoma,pathological process of eye tumor,occurrence of proliferating vitroretinopathy and diabetic retinopathy.Studies towards their functions are helpful for revealing the pathogenesis of eye diseases and providing new ideas of prevention and therapy.The distribution,source and eye disease-related action of TSP were summarized.

关 键 词：血小板反应蛋白 眼 生理 病理 

分 类 号：R77[医药卫生—眼科]