肿瘤干细胞作为胰腺癌治疗潜在靶点的研究进展  

Research progresses of cancer stem cells as emerging targets in pancreatic cancer

作　　者：孙宇[1] 孙宁[1] 杨绍时[1] 宋国栋[1] 

机构地区：[1]天津医科大学第二医院外科,天津300211

出　　处：《基础医学与临床》2014年第7期1006-1009,共4页Basic and Clinical Medicine

摘　　要：胰腺导管腺癌是最具侵袭性的肿瘤之一,对目前的治疗反应差和生存率低为其特点。最近肿瘤干细胞(CSC)在肿瘤生成中作用的研究进展使人们认识到CSC可作为新的治疗靶点。CSC是肿瘤细胞中一类明确的亚群,具有分化为其他细胞类型和为了保持肿瘤扩增而自我更新的能力。通过回顾CSC的生物标记和主要路径,似应找到以CSC为靶点的新的治疗方向。Pancreatic ductal adenocarcinoma is one of the most aggressive malignancies and is characterized by poor response to current therapy and a dismal survival rate.Recent insights regarding the role of cancer stem cells （CSC） in tumorigenesis have brought further understanding of the field and have highlighted new therapeutic targets.CSCs are a distinct subset of cancer cells,with the ability to differentiate into other cell types and self-renew in order to fuel the maintenance of tumor amplification.Here review the key pathways involved in these processes,the biomarkers used to identify CSC for finding new therapeutic approaches targeting CSC.

关 键 词：肿瘤干细胞 胰腺癌 上皮间质转换 

分 类 号：R735.9[医药卫生—肿瘤]