鳞状上皮细胞癌抗原联合液基薄层细胞检测在宫颈病变筛查中的价值  

The significance of the combination of serum SCC-Ag and TCT test in the screening of cervical lesions

作　　者：谭浩[1] 周桂华[1] 

机构地区：[1]湖南省妇幼保健院检验科,长沙410008

出　　处：《中国医师杂志》2014年第6期747-749,共3页Journal of Chinese Physician

基　　金：湖南省科技厅基金资助项目（2012SK3261）

摘　　要：目的：探讨鳞状上皮细胞癌抗原（SCC-Ag）联合液基薄层细胞检测（TCT）在宫颈病变筛查中的应用价值。方法TCT检测提示异常的58例患者，行病理活检，同时进行血清SCC-Ag检测，以病理活检为诊断标准，计算TCT与SCC-Ag联合检测筛查宫颈病变的敏感度、特异度，评价两者联合检测的诊断价值。结果 TCT检测的敏感度和特异度分别为75％和65.8％；SCC-Ag检测的敏感度和特异度分别为60％和86.9％；两者联合检测的敏感度和特异度分别为55％和89.4％。 TCT检测与SCC-Ag检测差异有统计学意义（ P ＜0.05），两者联合检测与单一TCT检测差异有统计学意义（ P ＜0.05）。结论TCT与SCC-Ag联合检测可提高宫颈检测的特异度，在宫颈病变筛查中具有一定的临床应用价值。Objective To explore the application of thinprep cytology test thinprep cytologic test （ TCT） and the serum squa-mous cell carcinoma antigen （ SCC-Ag） measurement in the cervical lesions screening .Methods TCT and serum SCC-Ag measure-ment were performed in 58 patients with cervical lesions .Based on pathology diagnosis , specificity and sensitivity of these two screen-ing methods were calculated .Results Sensitivity and specificity of TCT detection were 75%and 65.8%, the sensitivity and specific-ity of SCC-Ag detection was 60%and 86.9%, respectively, and specificity of combined detection were 55%and 89.4%, respective-ly.There was statistical significance in TCT test and SCC-Ag test （ P 〈0.05 ） , the difference had statistical significance of combined detection of both with a single TCT to detect differences （ P 〈0.05 ） .Conclusions The combination of TCT and SCC-Ag detection can improve specificity and there was a certain clinical application value in the screening of cervical lesions .

关 键 词：癌 鳞状细胞 免疫学 癌 鳞状细胞 血液 细胞诊断学 方法 宫颈疾病 诊断 普查 

分 类 号：R737.33[医药卫生—肿瘤]