环氧化酶2、X染色体连锁凋亡抑制蛋白在唾液腺恶性肿瘤中的表达及意义  

Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland

作　　者：宁兆荣[1] 李松[2] 郭延伟[1] 房殿吉[3] 

机构地区：[1]佳木斯大学附属口腔医院口腔颌面外科,黑龙江佳木斯154002 [2]长春市口腔医院口腔颌面外科,吉林长春130000 [3]复旦大学附属上海市第五人民医院口腔科,上海200240

出　　处：《上海口腔医学》2014年第3期317-321,共5页Shanghai Journal of Stomatology

基　　金：国家自然科学基金(81170935)~~

摘　　要：目的:检测环氧化酶2(Cox-2)与X染色体连锁凋亡抑制蛋白(XIAP)在唾液腺腺样囊性癌(ACC)与黏液表皮样癌(MEC)中的表达,探讨两者在唾液腺恶性肿瘤发生、发展中的作用及相关性。方法:采用免疫组织化学SP法检测95例唾液腺恶性肿瘤(包括50例ACC、45例MEC)、10例多形性腺瘤及10例正常唾液腺组织中Cox-2和XIAP的表达情况,使用SPSS17.0软件包对数据进行统计学处理。结果:Cox-2、XIAP在唾液腺恶性肿瘤中高表达,在多形性腺瘤和正常唾液腺组织中不表达或低表达。Cox-2、XIAP的表达与唾液腺恶性肿瘤组织临床分期和远处转移呈正相关(P<0.05),而与肿瘤部位无相关性(P>0.05)。结论:Cox-2和XIAP在唾液腺恶性肿瘤中高表达,可能在唾液腺恶性肿瘤发生、发展过程中具有重要作用。PURPOSE： To detect the expression of Cox-2 and XIAP in adenoid cystic carcinoma （ACC） and mucoepidermoid carcinoma （MEC） of salivary glands. To study the role and correlation between the expression of Cox-2 and XIAP in malignant tumors of salivary gland. METHODS： Immunohistoehemical SP staining method was used to quantify the protein expression levels of Cox-2 and XIAP in 95 patients with malignant tumors of the salivary gland （50 ACCs,45 MECs）,10 patients with pleomorphic adenoma and 10 persons with normal salivary gland tissues. SPSS17.0 software package was used to analyze the data. RESULTS： Cox-2 and XIAP were expressed strongly in malignant tumors of the salivary gland, while they not expressed in pleomorphic adenoma and normal salivary gland tissues. The expression of Cox-2 and XIAP in malignant tumors of salivary gland was correlated with clinical stage and lymphnode metastasis, while they not correlated with primary sites （P〉0.05）. CONCLUSIONS： The high expression of Cox-2 and XIAP in malignant tumors of salivary gland may play an important role in the development of malignant tumors of the salivary gland.

关 键 词：环氧化酶2 X染色体连锁凋亡抑制蛋白 腺样囊性癌 黏液表皮样癌 

分 类 号：R739.8[医药卫生—肿瘤]