TSG101与p21蛋白在胃腺癌中的表达及意义  

Expression of TSG101 and p21 proteins and their clinical pathologic significance in gastric adenocarcinoma

作　　者：杜红禹[1] 杨静[2] 高志安 

机构地区：[1]辽宁医学院病理学教研室,锦州121001 [2]辽宁医学院附属第一医院病理科

出　　处：《北京医学》2014年第7期575-577,共3页Beijing Medical Journal

摘　　要：目的：探讨肿瘤易感基因TSG101（Tumor susceptibility gene 101）及p21蛋白在胃腺癌中的表达及其临床意义。方法应用免疫组织化学方法检测80例胃腺癌及对应的癌旁2 cm胃黏膜组织中TSG101和p21蛋白的表达情况，结合临床资料分析其临床病理意义。结果①在胃腺癌组织及对应的癌旁2 cm胃黏膜组织中，TSG101蛋白的阳性表达率分别为35.0%和65.0%，p21蛋白阳性表达率分别为32.5%和67.5%，其差异有统计学意义（P＜0.05）；②TSG101蛋白阳性表达率在胃腺癌的高中分化组及无淋巴结转移组的阳性率为46.2%和67.6%，高于低分化组（14.3%）及有淋巴结转移组（10.9%），其差异均有统计学意义（P＜0.01）；而在不同TNM分期之间，则差异无统计学意义（P＞0.05）；③p21蛋白阳性表达率在高中分化组为44.2%，高于低分化组的10.7%，在无淋巴结转移组及TNMⅠ-Ⅱ组，p21蛋白阳性率分别为61.8%和41.8%，高于有淋巴结转移组及TNMⅢ组，组间差异均有统计学意义（P＜0.01）；④TSG101与P21蛋白之间未见相关性。结论 TSG101可能作为一个新的抑癌基因参与胃癌的发生发展过程，检测TSG101和P21蛋白的表达有助于判定胃腺癌的生物学行为。Objective To investigate the expression and the clinical pathological significance of TSG101 and p21 proteins expressed in gastric adenocarcinoma. Methods The expressions of TSG101 and P21 proteins were detected by immunohistochemical examinations in 80 cases of gastric adenocarcinoma and matched with the tissues 2cm adjacent to gastric mucosa （matched controls）. Results ① the positive rates of TSG101 protein were 35.0% and 65.0% in gastric adenocarcinoma and matched controls respectively, while the positive rates of P21 protein were 32.5% and 67.5%respectively. Statistically significant differences were obtained between the group of gastric adenocarcinoma and the group of the matched controls （P〈0.05）. ②Higher positive rate of TSG101 protein was found in the group with good tomoderate differentiation and non-lymph node metastasis patients than that of the poor differentiation and lymph node metastasis group （P〈0.01）,but no statistically significant differences was found among the groups in TNM stages; ③The positive expression rate of p21 protein in the group of good to moderate differentiation was higher than that in the poorly differentiation group;while in the group of non-lymph node metastasis and TNMⅠ-Ⅱ, the positive expression rate of P21 protein was higher than that in the group of lymph node metastasis and TNMⅢ （P〈0.01）; ④No association was found between the expression of TSG101 and p21 proteins in gastric adenocarcinoma. Conclusion It is suggested that TSG101 may contribute to the progression of gastric carcinoma and act as a potential tumor suppressor gene. The examination of the expression of TSG101 and p21 proteins may be helpful to the judgment of biological behaviors in the gastric carcinoma.

关 键 词：胃腺癌 TSG101 P21 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]