人附睾蛋白4和CA125联合检测在卵巢肿瘤的意义  

Significance of combined detection of HE4 and CA125 in ovarian tumors

作　　者：廖琳[1] 

机构地区：[1]郑州市第一人民医院检验科,450000

出　　处：《中国实用医刊》2014年第15期24-25,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨糖类抗原125（CA125）和人附睾蛋白4（HE4）的血清表达水平在鉴别诊断卵巢良、恶性肿瘤中的应用价值。方法用电化学发光法测血清CA125和人附睾蛋白的表达水平，包括卵巢癌40例，卵巢良性肿瘤疾病39例和女性健康体检者50例。结果CA125和HE4的表达水平在卵巢癌组明显高于其他两组，差异有统计学意义（P〈0．01）。良性组和健康组HF4水平比较差异无统计学意义（P〉0．05）。单独检测血清HE4含量对诊断卵巢癌的敏感性为71．70％，稍低于单独检测CA125的74．35％；但是HE4含量对卵巢癌的诊断特异性为88．89％，显著高于CA125的67．78％。而联合检测两者的敏感性为79．48％，特异性可达86．67％。结论血清CA125和HE4的联合检测有助于卵巢良、恶性肿瘤的鉴别诊断。Objective To investigate the combined detection of serum CA125 and HE4 levels in the differential diagnosis of ovarian benign tumor and ovarian cancer. Methods Serum levels of CA125 and HFA in 40 patients with ovarian cancer, 39 patients with benign ovarian benigntum or patients respectively, and 50 healthy controls were measured by electrochemoluminescence assay. Results Expression levels of CA125 and HFA in ovarian cancer group were significantly higher than those in the other two groups, the differences were statistically significant （ P 〈 0.01 ）. Serum levels of HF4 in benign and healthy groups showed no statistically significant difference （P 〉 0.05 ）. The sensitivity of serum levels of HE4 in the diagnosis of ovarian cancer was 71.70%, which was slightly lower than the sensitivity of CA125 alone （74. 35% ）; however, the diagnostic specificity of HE4 levels for ovarian cancer was 88.89%, which was significantly higher than the that of the CA125 （67.78%）. The sensitivity of joint detection was 79.48%, and the specificity was 86.67%. Conclusions Combined detection of serum HE4 and CA125 helps to the differential diagnosis of benign and malignant ovarian.

关 键 词：附睾上皮分泌蛋白4 糖类抗原125 卵巢癌 电化学发光 

分 类 号：R737.31[医药卫生—肿瘤]