幽门螺杆菌感染与胃食管反流病夜间酸突破的相关性探讨  

Correlation of Helicobacter pylori infection and gastroesophageal reflux disease relevance of nocturnal acid breakthrough

作　　者：杨雅娟[1] 王中平[2] 

机构地区：[1]邯郸市第一医院消化内科,河北邯郸056002 [2]河北省邯郸市第一医院急诊科

出　　处：《医药论坛杂志》2014年第6期48-50,共3页Journal of Medical Forum

摘　　要：目的 探讨幽门螺杆菌感染和胃食管反流病夜间酸突破的相关性。方法 选取邯郸市第一医院2012年6月-2013年6月收治的胃食管法流病患者100例作为研究对象，随机分为对照组和实验组，每组各有患者50例。对照组患者使用奥美拉唑治疗，实验组患者在对照组的基础上加服枸橼酸铋钾口服液，口服阿莫西林和甲硝唑，两组患者治疗疗程均为10天。检查患者22点～次日凌晨8点期间夜间酸突破情况，并对患者进行RDQ评分。结果 对照组患者夜间酸突破的发生率为22．0％，显著低于实验组的52．0％，差异有统计学意义（P〈0．05）；对照组和实验组患者经治疗ROD评分均显著下降，与治疗前相比差异有统计学意义（P〈0．05）；治疗前后两组患者组间比较差异无统计学意义（P〉0．05）。结论 胃食管反流病症状的发生不依赖夜间酸突破，幽门螺杆菌是胃食管反流病的保护因素，清除幽门螺杆菌会加重夜间酸突破的发生。Objective To investigate the correlation of Helicobacter pylori infection and gastroesophageal reflux disease nocturnal gastric acid breakthrough. Methods A hospital in June 2012 - Jane 2013 treated patients with gastroesopbageal flow method for the study 100 cases were randomly divided into control and experimental groups, each group of 50 patients. Control group of patients using omeprazole treatment, patients in the control group, the experimental group on the basis of additional services bismuth potassium citrate oral solution, oral amoxicillin and metronidazole, two groups of patients were 10 days treatment. Check the patient 22：00 ～ 8：00 the next day during the nocturnal gastric acid breakthrough in the situation, and in patients with RDQ score. Results In the control group, the incidence of nocturnal acid breakthrough was 22. 0%, significantly lower than 52.0% of the experimental group, the difference was statistically significant （ P 〈 0. 05 ） ; The control group and the experimental group were treated ROD scores were significantly decreased, and before treatment, the difference was statistically significant （P 〈 0. 05） ; Patients before and after treatment between the two groups showed no significant difference （P 〉 0.05 ）. Conclusion The occurrence of symptoms of gastroesophageal reflux disease does not depend nocturnal acid breakthrough, Helicobacter pylori is a protective factor for gastroesophageal reflux disease, helicobacter pylori clearance will increase the occurrence of nocturnal acid breakthrough.

关 键 词：幽门螺杆菌 胃食管反流病 夜间酸突破 

分 类 号：R571[医药卫生—消化系统]