GSTM1和GSTP1基因多态性对接受铂类药物化疗的肺癌患者疗效的影响  

Impact of GSTM1 and GSTP1 polymorphism on lung cancer patients treated with platinum-based chemotherapy

作　　者：李启英[1] 童永红[1] 黄露迷[1] 冀晓辉[1] 杨燕青[2] 李代蓉[1] 

机构地区：[1]重庆市肿瘤研究所肿瘤内科,400030 [2]生物芯片上海国家工程研究中心,上海201203

出　　处：《重庆医学》2014年第20期2592-2594,2597,共4页Chongqing medicine

摘　　要：目的研究谷胱甘肽S-转移酶M1(GSTM1)基因和谷胱甘肽S-转移酶P1(GSTP1)基因单核苷酸多态性(SNP)与非小细胞肺癌(NSCLC)化疗敏感性的关系。方法分别应用基因测序法和PCR法检测89例以铂类药物为主要化疗方案的NSCLC患者外周血GSTM1和GSTP1DNA基因型,所有肺癌患者经过两周期含铂化疗后进行疗效评价,比较不同基因型与化疗疗效的关系。结果 89例患者化疗总有效率为29.2%。GSTP1Ile105Val基因型和GSTM1基因型在化疗有效组和无效组之间差异无统计学意义(P>0.05)。结论 GSTP1Ile105Val基因型和GSTM1基因型SNP可能与NSCLC化疗耐受无关。Objective To investigate the relationship between glutathione S-transferases P1（GSTP1）Ile105Val and glutathione S-transferases M1（GSTM1）single nucleotide polymorphisms（SNP） and the sensitivity to chemotherapy among patients with ad-vanced non-small cell lung cancer（NSCLC） .Methods We used gene sequencing analysis to determine the SNP of GSTP1 Ile105Val and PCR analysis to GSTM1 in DNA from peripheral lymphocytes of NSCLC patients .Totally 89 patients with NSCLC were trea-ted with platinum-based chemotherapy ,and clinical response was evaluated after 2 cycles .The association between GSTP1 Ile105Val and GSTM1 SNP and chemosensitivity were analyzed .Results The overall response rate was 29 .2% .Chemotherapy re-sponse did not show statistically significant differences between the wild genotypes and the variant genotypes for the GSTP1 Ile105Val and GSTM1 gene（P〉0 .05） .Conclusion The polymorphisms of GSTP1 Ile105Val and GSTM1 may be not associated with sensitivity to chemotherapy in NSCLC patients .

关 键 词：多态性 单核苷酸 肺肿瘤 GSTP1 GSTM1 化疗 

分 类 号：R734.2[医药卫生—肿瘤]