肝素酶和CD44v6在非小细胞肺癌中的表达及意义  

The significance of heparanase and CD44v6 expressing in non-small cell lung cancer

作　　者：邓太兵[1] 黄万秀 唐凤鸣[2] 

机构地区：[1]四川省广安市人民医院呼吸内科,638500 [2]四川省宜宾市第一人民医院呼吸内科,644000

出　　处：《重庆医学》2014年第20期2606-2608,共3页Chongqing medicine

摘　　要：目的探讨CD44v6和肝素酶在非小细胞肺癌(NSCLC)及癌旁正常肺组织中的表达情况,并研究其与NSCLC侵袭、转移中的关系。方法采用免疫组织化学染色检测117例NSCLC组织及其中62例患者癌旁正常肺组织中CD44v6及肝素酶的表达情况,并研究二者之间的相关性。结果 CD44v6在NSCLC中的阳性表达率为54.7%(64/117),显著高于癌旁正常组织中的阳性表达率[4.8%(3/62)];肝素酶在NSCLC中的表达率为86.3%(101/117),显著高于正常癌旁组织的阳性表达率[17.7%(11/62)];CD44v6在NSCLC中的表达与肝素酶的表达具有相关性。结论 CD44v6和肝素酶与NSCLC的侵袭转移相关,联合检测二者的表达,可能对判断NSCLC的预后具有一定的参考价值。Objective To investigate the CD44v6 and heparanase in non-small cell lung cancer （NSCLC ） and adjacent normal lung tissues ,and to study the correlation of these two molecular in non-small cell lung cancer invasion and metastasis .Methods The expressing of CD44v6 and heparanase in 117 patients with non-small cell lung cancer tissues and 62 adjacent normal lung tissue was detected by immunohistochemical staining .Results The expression of CD44v6 in NSCLC was 54 .7% （64/117） ,which was sig-nificantly higher than in adjacent tissues of 4 .8% （3/62）（P〈0 .05）;the expression of heparanase in NSCLC was 86 .3% （101/117） ,which was significantly higher than the normal adjacent tissues 17 .7% （11/62）（P〈0 .01）;CD44v6 expression in NSCLC ex-pression was positive correlated with heparanase .Conclusion CD44v6 and heparanase are associated with the invasion and metasta-sis of NSCLC ,combined detection of the expression of the two molecular maybe has a certain reference value in determine the prog-nosis of NSCLC .

关 键 词：癌  非小细胞肺 肝素裂合酶 肿瘤转移 CD44V6 

分 类 号：R734.2[医药卫生—肿瘤]