Fas-670基因多态性与青海地区乳腺癌临床病理指标间的关系  

The association between Fas-670 gene polymorphisms and clinic pathologic index of breast cancer in Qinghai district

作　　者：黄欣[1] 胡英[1] 王秀娟[1] 金丽艳[2] 张双元[2] 

机构地区：[1]青海大学医学院实验诊断教研室,西宁810001 [2]青海大学附属医院乳甲外科,西宁810001

出　　处：《重庆医学》2014年第20期2617-2619,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(30960359)

摘　　要：目的研究Fas-670基因多态性与青海地区乳腺癌临床病理指标的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法,检测了232例青海女性乳腺癌患者Fas-670基因多态性,用χ2检验分析其基因多态性与乳腺癌临床病理指标间的关系。结果 232例乳腺癌中,Fas-670基因多态频率分布:纯合野生型AA为39.7%(92/232)、杂合型AG为48.7%(113/232)、纯合突变型GG为11.6%(27/232)。Fas-670基因型与青海乳腺癌临床病理指标无相关性(P>0.05)。结论Fas-670基因多态性与青海地区乳腺癌临床病理指标无联系。Objective To investigate the correlation between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district .Methods The polymorphisms of Fas-670 gene were detected by polymerase chain reaction-restric-tion fragment length polymorphisms assay （PCR-RFLP） in 232 female breast cancer patients ,χ2 test was applied to assess the asso-ciation between the polymorphisms of Fas-670 gene and breast cancer clinic pathologic index .Results In 232 breast cancer pa-tients ,the frequency of Fas-670 homozygous wild type（AA） ,heterozygous type（AG） ,homozygous mutant type（GG） were 39 .7%（92/232） ,48 .7% （113/232） ,11 .6% （27/232） respectively .It was no statistical significance between Fas-670 gene polymorphisms and the clinic pathologic index of breast cancer in Qinghai district（P〉0 .05） .Conclusion The polymorphisms of Fas-670 gene is not associated with clinic pathologic index of breast cancer in Qinghai district .

关 键 词：乳腺肿瘤 FAS-670 基因多态性 临床病理指标 

分 类 号：R737.9[医药卫生—肿瘤]