区域人群肺癌危害性风险评估基本理论、技术和方法研究  

A Study on Theory,Technique,Method of Hazards Assessment to Lung Cancer in Region Population

作　　者：张川[1,2] 高星[1,2] 

机构地区：[1]首都医科大学公共卫生学院,北京100069 [2]首都医科大学环境毒理学北京市重点实验室,北京100069

出　　处：《中国肿瘤》2014年第7期567-573,共7页China Cancer

基　　金：北京市自然科学基金重大项目(2011-7110001)

摘　　要：[目的]建立肺癌危害性评估理念、基本理论、技术和方法及指标体系框架,为区域人群肺癌风险评估提供基础依据和技术支撑。[方法]采用标准判断法、资料分析法和矩阵分析法,依据ISO风险评估标准,对全人群、生命全周期和疾病全过程及其相关危险因素进行分类分层分析,建立肺癌危害性评估(一类)指标。[结果]提出区域人群肺癌危害性风险评估的理念、基本理论;建立了危害性评估指标体系,一级指标2个,二级指标8个,三级指标18个,并分别赋予权重系数、四级评分标准。确立区域人群肺癌危害性风险矩阵评估方法。[结论]依据风险、公众健康风险和肺癌风险分析原理,较为全面系统地构建了区域人群肺癌危害性风险评估基本理论框架,建立一类四级危害性风险评估指标体系、权重系数、评分依据和矩阵评估方法,为肺癌风险评估提供技术支持和科学依据。[Purpose] To establish the concept,basic theory,technique and method and indicators system framework for hazard assessment of lung cancer in region population, and to provide the scientific support basis of risk assessment of human lung cancer. [Methods] Systemically estab- lishing criteria for judging method,data analysis,analytic hierarchy process and matrix method, risk assessment based on ISO standards for the whole population （healthy population, early damage population, lung cancer incidence and death population）, the whole life time and the whole process of the disease and its associated risk factors were carried out by stratified analysis. Hazard assess- ment indicators of lung cancer was established. [Results] The basic theory of lung cancer hazard assessments in regional population was proposed. The hazards evaluation index system, including the first level indicators of class 2, the secondary level indicators of class 8, and the third level in- dicators of class 18 was established. And the weight coefficients and four scoring criteria was giv- en. The lung hazard assessment methods was established. [Conclusion] This article from public health risks and lung cancer risk analysis, a more comprehensive and systematic theoretical frame- work is established to assess risk of lung cancer,to determine the risk factors and the severity of the hazard assessments based on a four index system,weight coefficients and matrix method,to provide technical support for lung cancer risk assessment.

关 键 词：肺癌 危害性风险评估 指标体系 矩阵方法 

分 类 号：R734.2[医药卫生—肿瘤]