克罗恩病患者肠道菌群结构与血沉等指标关系的研究  

Relationship between structure changes of intestinal flora and blood sedimentation,c-reactive protein and TNF-αin patients with Crohn disease

作　　者：林述洲[1] 林焕雄[1] 

机构地区：[1]潮州市中心医院消化内科,广东潮州521021

出　　处：《中国校医》2014年第7期530-532,共3页Chinese Journal of School Doctor

摘　　要：目的探讨克罗恩病(CD)患者肠道菌群结构的变化及与血沉(BS)、C反应蛋白(CRP)和TNF-α的关系。方法将150例我科收治的腹痛低热患者分为CD组(n=56)和非CD组(n=94),另选取30例健康者组成对照组,检查3组样本肠道菌群结构的变化及BS、CRP和TNF-α水平并分析其与肠道菌群结构的变化的关系。结果与对照组比较,非CD患者肠杆菌、酵母菌、拟杆菌等细菌的数量均增加而真杆菌的数量则显著下降,CD病组肠杆菌、酵母菌、拟杆菌等细菌的数量均增加而真杆菌和小梭菌的数量则显著下降,CD组和非CD组患者BS、CRP和TNF-α水平均增加,与非CD组比较,CD组BS、CRP和TNF-α水平均增加,随着患者BS、CRP和TNF-α水平的提高,CD组的肠球菌数量与非CD组的酵母菌数量均增加(P<0.05)。结论 CD患者肠道菌群结构的变化与BS、CRP和TNF-α水平及真菌减少相关。Objective To explore the relationship between the changes of the structure of intestinal flora and blood sedimentation（BS）,c-reactive protein（CRP）and TNF-αin the patients with Crohn disease（CD）. Methods A total of 150 patients with abdominal pain and low thermal were divided into a CD group（n=56）and a non-CD group（n=94）,and the control group was formed by 30 healthy persons.The intestinal flora structure changes,BS,CRP and TNF-αlevels of the 3groups were tested and the relationships between the structure change of intestinal flora and BS,CRP and TNF-αwere analyzed respectively. Results Compared with the control group,the number of enterobacteria,microzyme,bacteroid and other bacteria in the non-CD group and CP group were increased while the number of eubacterium was decreased,and the number of clostridium in the CD group was also significantly reduced（all P〈0.05）.The BS,CRP and TNF-αlevels in the non-CD group and CD group were increased,and the BS,CRP and TNF-αlevels in the CD group were higher than those of the nonCD group（all P〈0.05）.With the increases of BS,CRP and TNF-αlevels,the number of enterobacteria in the CD group and the number of microzyme in the non-CD group were increased（P〈0.05）. Conclusions The structure change of intestinal flora in patients with CD are correlated with the BS,CRP and TNF-αlevels and fungi reducing.

关 键 词：CROHN病 肠黏膜 微生物学 血沉 C反应蛋白 肿瘤坏死因子-Α 

分 类 号：R515[医药卫生—内科学]