多药耐药相关蛋白、P53蛋白在乳腺癌中的表达  

The Expression of MRP and P53 in Breast Cancer and its Clinical Significance

作　　者：张馨[1] 毛大华[1] 邓英蕾[1] 

机构地区：[1]贵阳医学院附院乳腺外科,贵州贵阳550004

出　　处：《贵阳医学院学报》2014年第3期336-339,共4页Journal of Guiyang Medical College

摘　　要：目的:探讨人乳腺癌组织中多药耐药相关蛋白(MRP)与P53蛋白的表达及关系。方法:采用免疫组化方法检测43例手术切除的乳腺癌标本中MRP与P53蛋白的表达,17例乳腺纤维腺瘤标本作为对照。结果:乳腺癌组织中MRP、P53蛋白的阳性率显著高于乳腺纤维腺瘤组(P<0.05);MRP的表达水平与年龄、月经状况、肿瘤大小、有无淋巴结转移、病理类型及TNM分期无关(P>0.05);P53蛋白的表达在有淋巴结转移时显著高于无淋巴结转移时,与年龄、月经状况、肿瘤大小、病理类型及TNM分期无关(P>0.05);MRP的阳性表达率与P53蛋白表达高低呈正相关(r=0.396)。结论:MRP表达程度不受乳腺癌病程发展的影响,P53蛋白与乳腺癌的发生、发展有关,对评估患者预后可能具有重要意义,P53蛋白对乳腺癌中MRP的表达可能起调控作用。Objective： To investigate human breast tissue for multidrug resistance-associated protein （MRP） and P53 protein expression, to learn the relationship among their expression and the clinical pathologic parameters. Methods： The expressions of MRP and P53 were detected in 43 cases of breast cancer and 17 cases of fibroadenoma by using immunohistochemical SABC method. We analyzed the expression of the two-factors in the two groups and their connections with age, menstruation status, tumor~ size, lymph node metastasis, TNM stages and the pathological types and their correlation be- tween each other. Results： Positive expression ratios of MRP and P53 in breast cancer were signifi- cantly higher than those in fibroadenoma. （ P 〈 0.05 ） ; MRP expression was not significantly correlated with age, menstruation status, tumor~ size, lymph node metastasis, TNM stages, and the pathological types （P 〉 0.05 ） ; P53 expression was correlated with lymph node metastasis. （ P 〈 0.05 ）. while it was not significantly correlated with age, menstruation status, tumor＇s size, TNM stages, and the path- ological types. （P 〉 0.05 ）. The expression of MRP was positively correlated with P53 expression. （P 〈0.05 ）, and MRP positive expression in breast cancer was associated with higher P53 expression（ r = 0. 396 ,P 〈 0.01 ）. Conclusions： These results suggest there may be an intrinsic drug resistance ex- isting in breast cancer, it~ expression is not influenced by the progression of breast cancer. P53 is cor- related with the genesis and progression of breast cancer, it might be a useful marker for predicting the lymph node metastasis and the prognosis of breast cancer. The expression of apoptosis-related gene P53 is significantly related to muhidrug resistance factors MRP, it supports the phenomenon of effect of P53 on MRP expression. regnlating

关 键 词：癌 乳腺肿瘤 多药耐药相关蛋白质类 蛋白质P53 

分 类 号：R363.21[医药卫生—病理学] R737.9[医药卫生—基础医学]