禽流感病毒结膜炎的流行及其眼嗜性的分子基础  

Epidemics of conjunctivitis caused by avian influenza virus and molecular basis for its ocular tropism

作　　者：杨潮[1] 金明[1] 

机构地区：[1]中日友好医院眼科,北京100029

出　　处：《中华眼科杂志》2014年第7期550-552,共3页Chinese Journal of Ophthalmology

摘　　要：禽流感病毒已经导致多起人类禽流感的暴发,给人类带来重大的灾难.2013年在我国流行的H7N9禽流感,重新唤起了我们对人感染禽流感的重视.越来越多的证据表明,眼是禽流感病毒感染人类的入侵途径之一,导致结膜炎.目前研究表明,只有禽流感病毒H7和H5亚型可以导致系统的严重感染,禽流感病毒的入侵可能与结膜和角膜上α-2,3唾液酸糖苷受体较为丰富有关;另外,H7亚型能特异激活NF-κB信号转导通路也与其眼嗜性相关.这些研究提示,对于临床医师而言,在流感流行季节诊断结膜炎过程中要注重与禽流感病毒感染的鉴别;对于疾控人员在处置禽流感疫情时,需要加强眼睛的防护.本文就禽流感病毒结膜炎的流行及其眼嗜性的分子基础做一综述.Avian influenza virus （AIV） has caused several outbreaks in humans,leading to disasters to human beings.The outbreak of H7N9 avian influenza in China in 2003 re-attracted our close attention to this disease.More and more evidences demonstrated that eye is one of invasion portals of AIV,leading to conjunctivitis.The current studies showed that only subtypes H7 and H5 could cause severe systemic infections.Abundant distribution of α-2,3 siliac acid receptor in conjunctiva and cornea as well as specific activiation of NF-κB signal transduction pathway by subtype H7 virus may contribute to the ocular tropism of the virus.These studies suggest that avian influenza conjunctivitis should be considered as a differential diagnosis during influenza epidemic seasons,and eyes should be well protected for disease control personnel when handling avian influenza epidemics.This review focused on AIV conjunctivitis and the molecular basis of ocular tropism.

关 键 词：正黏病毒科感染 结膜炎 病毒性 病毒嗜性 病毒复制 上皮细胞 

分 类 号：R777.31[医药卫生—眼科]