老年急性脑梗死患者血浆8-异前列腺素F2α与神经功能缺失程度的关系  

Correlation of Serum 8-iso-PGF2α Level and the Severity of Neurological Deficits in Elderly Patients with Cerebral Infarction

作　　者：郑海建[1] 谢燕[2] 张化民[1] 秦华[1] 

机构地区：[1]江苏省赣榆县人民医院老干部科,222100 [2]苏州大学附属第一医院特需病房

出　　处：《天津医药》2014年第7期701-703,共3页Tianjin Medical Journal

基　　金：连云港市"科教兴卫工程"青年科技项目(Q1214)

摘　　要：目的探讨老年急性脑梗死患者血浆8-异前列腺素F2α(8-iso-PGF2α)的变化及与神经功能缺失程度的关系。方法将67例急性脑梗死患者分为中青年组30例(<60岁)和老年组(≥60岁)37例,另择30例健康体检者(≥60岁)为老年对照组。采用ELISA法检测脑梗死患者血浆8-iso-PGF2α水平,采用美国国立卫生研究院脑卒中量表(NIHSS)评分进行神经功能缺损评估。结果老年组血浆8-iso-PGF2α水平(506.38±138.63)ng/L高于老年对照组(369.98±99.81)ng/L和中青年组(420.18±132.72)ng/L,中青年组与老年对照组差异无统计学意义(F=9.272,P<0.05)。老年组NIHSS评分高于中青年组[(19.78±3.66)vs(17.73±2.70),t=2.539,P<0.05]。老年组血浆8-iso-PGF2α与NIHSS评分呈正相关(r=0.504,P=0.001)。结论氧化应激在老年急性脑梗死患者的发生、发展过程中起着重要的作用,尽早合理的抗氧化治疗可以减轻临床症状,促进病情恢复。Objective To investigate the relationship between the level of 8-iso-prostaglandin （8-iso-PG）F2αand the neural functional deficit in patients with acute cerebral infarction （ACI）. Methods Sixty-seven ACI patients were se-lected in Neurological Department of Ganyu People’s Hospital. According to the age, these subjects were divided into two groups：the old group （≥60 years, n=37） and middle-young group （〈60 years, n=30）. Thirty healthy subjects were selected as controls （≥60 years）. The age, gender and anamnesis were matched in two groups of elderly people. The ELISA was used to detect the plasma levels of 8-iso-PGF2αin two groups of patients. And NIHSS score was used to evaluate the severity of clinical neurological deficit. Results The plasma levels of 8-iso-PGF2α were significantly higher in old ACI group （506.38±138.63） ng/L than those of middle-young ACI group （420.18±132.72） ng/L and old control group （369.98±99.81） ng/L. There was no significant difference in plasma level of 8-iso-PGF2αbetween middle-young ACI group and old control group （F=9.272,P〈0.05）. The NIHSS score was significantly higher in old group （19.78±3.66） than that of middle-young group （17.73 ± 2.70, t=2.539,P〈0.05）. There was a positive correlation between plasma 8-iso-PGF2α level and NIHSS score in old group （r=0.504,P=0.001）. Conclusion The oxidative stress plays an important role in the occurrence and de-velopment process of ACI in elderly patients. The earlier and reasonable antioxidant therapy plays a positive role to alleviate the clinical symptoms and promote the recovery of illness.

关 键 词：脑梗死 异前列腺素 氧化应激 8-异前列腺素F2Α 老年 

分 类 号：R743[医药卫生—神经病学与精神病学]