转录因子SOX2在胃癌中的表达及其临床意义  

Expression of SOX2 in gastric carcinoma and its clinical significance

作　　者：牛艳清[1] 邓丽英[1] 王云峰[1] 余沙[1] 吴九喜 皇甫娇阳 

机构地区：[1]长治医学院病理学教研室,046000

出　　处：《肿瘤研究与临床》2014年第6期394-396,共3页Cancer Research and Clinic

摘　　要：目的 探讨转录因子SOX2在胃癌组织中的表达情况及其与临床病理特征的关系.方法 应用免疫组织化学技术检测67例胃癌组织中SOX2的表达,并选取30例远端切缘胃壁组织作为对照.结果 SOX2在胃癌组织中的阳性表达率为52.24％（35/67）,显著低于对照组胃壁组织的阳性表达率93.33％（28/30）,差异有统计学意义（χ^2=16.326,P＜ 0.01）;在胃癌组织中SOX2的阳性表达率与肿瘤的分化程度、浸润深度、淋巴结转移以及临床分期有关,差异均有统计学意义（均P＜ 0.05）.结论 SOX2表达下调与胃癌的早期发生有关,并与淋巴结转移及TNM分期密切相关,SOX2可作为预测胃癌预后的生物学指标.Objective To investigate the expression of SOX2 in gastric carcinoma and to analyze its relationship with clinicopathological features.Methods Immunohistochemistry method was used to detect the level of SOX2 in 67 cases of gastric carcinoma group and 30 cases of normal gastric mucosa group.Results The positive expression rate of SOX2 in gastric carcinoma group （52.24 %） was obviously lower than that in normal gastric mucosa group （93.33 %） （χ^2 =16.326,P 〈 0.01）.The SOX2 expression was significantly correlated with differentiation,the depth of invasion,lymph node metastasis and TNM stage of the tumor （all P 〈 0.05）.Conclusions The low expression of SOX2 may contribute to the early carcinogenesis of gastric carcinoma,and the expression level of SOX2 is closely related with lymph node metastasis and TNM stage.The expression level of SOX2 is a useful marker for predicting the prognosis of gastric carcinoma.

关 键 词：胃肿瘤 SOX2 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]