天麻素联合多奈哌齐治疗血管性痴呆疗效分析  

Clinical efficacy of gastrodin and donepezil on vascular dementia

作　　者：何小波 王晓燕[2] 

机构地区：[1]湖北医药学院附属人民医院老年病科,湖北省十堰市442000 [2]湖北医药学院附属人民医院神经内科,湖北省十堰市442000

出　　处：《实用老年医学》2014年第7期580-582,共3页Practical Geriatrics

摘　　要：目的观察天麻素与多奈哌齐联合治疗血管性痴呆的临床治疗效果。方法我们采用随机、对照研究的方法,将48例老年血管性痴呆患者分为多奈哌齐组(对照组)、多奈哌齐联合天麻素治疗组(联合治疗组),观察2组患者简易智能量表、日常生活功能量表、Hachinski缺血量表及脑电图等指标的变化,并观察不良反应。结果研究显示2组痴呆量表评分、生活质量评分及脑电图表现均有明显改善,而药联合治疗组改善更明显,与对照组比较有统计学差异。结论天麻素联合多奈哌齐能改善血管性痴呆患者生活质量及脑功能。Objective To observe the therapeutic effect of gastrodin and donepezil on vascular dementia. Methods Forty-eight elderly patients were divided into two groups （the donepezil group vs the donepezil plus gastrodin group） randomly.The mini-mental state examination （MMSE）, activity of daily living （ADL）, Haehinski ischemic score and the EEG expression were evaluated and the adverse effect was observed. Results The cognitive function, the ability of activity of daily living, and the EEG expression were improved in two groups after treatment. The donepezil plus gastrodin group has even more better therapeutic effect compared with the donepezil group, which were inflected in higher score in MMSE, lower score in ADL, and higher α band relative power value and lower 0 and ~ band relative power value in quantitative EEG. Conclusions Donepezil plus gastrodin have even more better effect on vascular dementia.

关 键 词：血管性痴呆 天麻素 多奈哌齐 

分 类 号：R749.13[医药卫生—神经病学与精神病学]