气滞胃痛颗粒促胃肠动力作用谱效关系网络模型的构建  

Establishment of Spectrum-effect Relationship Network Model of Qizhiweitong Granules Promoting Gastrointestinal Motility

作　　者：包永睿[1,2] 王帅[1,2] 孟宪生[1,2] 杨欣欣[1,2] 崔亚玲[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]辽宁省组分中药工程技术研究中心/辽宁省现代中药研究工程实验室,辽宁大连116600

出　　处：《中药材》2014年第5期828-832,共5页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(81241111)

摘　　要：目的:构建气滞胃痛颗粒促胃肠动力作用谱效关系网络模型,为其合理质量控制与药效评价提供科学依据。方法:采用拉丁超立方法随机抽样,建立气滞胃痛颗粒中6味药材20个不同配伍组的全时段多波长融合指纹图谱;同时测定各配伍组小肠平滑肌细胞的增殖率、cGMP含量和NO含量;采用灰色关联分析法与BP神经网络,将药效的综合信息与不同配伍组的谱图信息进行相关性分析,从而构建二者谱效关系网络模型。结果:从气滞胃痛颗粒36个化学成分中,找到20个与促胃肠动力作用相关系数大于0.9的成分,成功建立了气滞胃痛颗粒促胃肠动力作用谱效关系网络模型,通过该模型对试验结果进行预测,其相对误差的绝对值均小于6.83%。结论:本实验通过构建气滞胃痛颗粒促胃肠动力作用谱效关系网络模型,为其合理的质量控制与药效评价提供了全新的研究方法,同时为复方组-效研究奠定实验基础,也为其他中药复方谱效关系研究提供参考。Objective：To establish the spectrum-effect relationship network model of Qizhiweitong granules promoting gastrointesti- nal motility for providing scientific basis for its quality control and efficacy evaluation. Methods：The Latin hypercube sampling was used to establish full-time multi-wavelength fusion fingerprints of different compatibility groups of Qizhiweitong granules. At the same time, the appreciation rate, the contents of cGMP and NO in small intestine smooth muscle cells after administrated drugs were deter- mined. Then the spectrum-effect relationship of different compatibility groups were correlated, and the network model was established with gray correlation method and BP neural network. Results ：20 compounds with correlation index more than 0. 9 were found from 36 constituents in Qizhiweitong granules. The spectrum-effect relationship network model of Qizhiweitong granules promoting gastrointestinal motility was successfully established. And through this model to forecast the result of the test, the absolute value of the relative error was less than 6. 83%. Conclusion：In this study, a spectrum-effect relationship network model of Qizhiweitong granules promoting gastrointes- tinal motility is established suecessfully, which provides a new method for its reasonable quality control and efficacy evaluation,lays the experiment basis for component-effect study,and provides reference for other TCM＇s study.

关 键 词：气滞胃痛颗粒 促胃肠动力 谱效关系 网络模型 

分 类 号：R285.5[医药卫生—中药学]