黄皮根和茎中一个新的木脂体(英文)  

A New Cytotoxic Oxyneolignan from the Roots and Stems of Clausena lansium( Rutaceae)

作　　者：宋卫武[1,2] 曾广智[1] 彭文文[1] 谭宁华[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201 [2]中国科学院大学,北京100049

出　　处：《植物分类与资源学报》2014年第4期545-550,共6页Plant Diversity

基　　金：Found of the National New Drug Innovation Major Project of China(2011ZX09307-002-02);the National Natural Science Foundation of China(U1032602 and 91013002);the National Basic Research Program of China(2009CB522300);the Fund of Chinese Academy of Sciences(Hundred Talents Program);the Natural Science Foundation of Yunnan Province(2012GA003)

摘　　要：从黄皮(Clausena lansium)根和茎中分离得到8个化合物,其中化合物claulignan(1)为一个新的木脂体类化合物,通过1D-、2D-NMR和高分辨质谱确定其结构。化合物2-8首次从黄皮属(Clausena)植物中分离得到。活性筛选结果表明,化合物1和6显示一定的细胞毒活性,对人宫颈癌HeLa细胞株的IC50分别为25.03和53.99μM;化合物3具有一定的抗氧化活性,在DPPH实验中的EC50为268.96g·kg-1。A new oxyneolignan, claulignan （1）, together with seven known compounds （2-8）, were isolated from the methanol extract of the roots and stems of Clausena lansium. Their structures were elucidated on the basis of 1D- and 2D-NMR experiments and mass spectrometry. Compounds 2-8 were isolated from the genus Clausena for the first time. Compounds 1 and 6 showed cytotoxicity against human cervical cancer HeLa cell line with the IC50 values of 25.03 and 53.99μM, respectively. Compound 3 exhibited antioxidant activity in the DPPH assay with the EC50 value of 268.96 g· kg-1.

关 键 词：黄皮 木脂体 细胞毒 DPPH Claulignan 

分 类 号：Q946[生物学—植物学]