玉米多糖的抗衰老作用  

The Anti-Aging Effect of Crude Corn Polysaccharides

作　　者：张钟[1] 高红梅[2] 叶林杰[2] 

机构地区：[1]广东石油化工学院,茂名525000 [2]安徽科技学院,凤阳233100

出　　处：《中国粮油学报》2014年第7期18-21,共4页Journal of the Chinese Cereals and Oils Association

基　　金：广东省引进人才基金(201192);广东石油化工学院人才引进基金(2010r2)

摘　　要：本试验探讨了玉米活性多糖的抗衰老作用。未配对的雌雄小鼠被随机分成五组:衰老模型组,正常对照组,低剂量组,中剂量组和高剂量组,除正常对照组外均为D-半乳糖致衰老模型小鼠。五周后将实验小鼠处死,取其血清,大脑,肝脏和肾脏分别测得超氧化物歧化酶(SOD)、谷光甘肽过氧化物酶(GSH-PX)、过氧化氢酶(CAT)的活性和丙二醛(MDA)等相关指标。结果表明:①从衰老模型组、空白组、低剂量组、中剂量组到高剂量组,SOD,GSH-PX和CAT活力均呈上升趋势,3个剂量组血清及各脏器中的SOD、GSH-PX活力与衰老模型组均存在显著性差异(P<0.05),量效关系呈正相关趋势;②各剂量组与衰老组相比血清和各脏器中的MDA含量均显著下降(P<0.05),且量效关系呈负相关趋势。而高剂量组小鼠的SOD、GSH-PX和CAT活力增加比其他各组更显著,MDA含量更低。所以,玉米多糖可以提高D-半乳糖致衰老小鼠的SOD、GSH-PX和CAT活性,降低MDA含量,从而具有抗衰老作用。Mice have been treated as the experimental animal to study the anti - aging effect of corn active polysaccharides（CAP）. Unmated female and male mice were respectively and randomly divided into five groups as： senile model group, normal group, low dose group, medium dose group and high dose group. The mice were measured with anti - aging test except the normal group. After five weeks the activities of superoxide dismutase （ SOD）, glutathione peroxides（ GSH - Px）, catalase（CAT） and the content of malondialdehyde（MDA） in the serum, brain, liver and kidney of senescence - accelerated mice were measured respectively. The results showed that： （1） As the turn of senile model group, normal group, low dose group, medium dose group to high dose group, the activities of SOD, GSH -PX and CAT in serum, brain, liver and kidney（p 〈 0.05 ）increased significantly; （2） Compared with the senile model group, contents of MDA in serum, brain, liver and kidney（p 〈 0.05 ） decreased significantly ; The conclusion： CAP may postpone senility, which mechanism probably connect with rising immunity, eliminating oxygen free radicals, anti -lipoperoxidation and dropping MDA to express a anti -aging effect.

关 键 词：玉米多糖 抗衰老 超氧化物歧化酶 谷光甘肽过氧化物酶 过氧化氢酶 

分 类 号：Q539[生物学—生物化学]