骨疏灵颗粒防潮辅料优选  

Optimization of damp-proof excipients for Gushuling Granules

作　　者：朱裕林[1,2] 张兰[2] 彭祥雪[2] 陈卫东[2] 

机构地区：[1]蚌埠医学院第一附属医院药剂科,安徽蚌埠233004 [2]安徽中医药大学药学院,安徽合肥230031

出　　处：《中草药》2014年第14期2005-2008,共4页Chinese Traditional and Herbal Drugs

基　　金：安徽省自然科学基金资助项目(1208085MH127)

摘　　要：目的评价辅料对骨疏灵吸湿性的影响,优选骨疏灵颗粒剂防潮辅料。方法通过吸湿率考察优选辅料的种类及配比;从乙醇浓度、吸湿率、成型性、休止角、颗粒外观等方面优选成型工艺。结果骨疏灵颗粒的最佳防潮混合辅料为乳糖-甘露醇(4∶1),药辅比1∶2;85%乙醇制粒,颗粒大小均匀,成型性较好,临界相对湿度76%。结论为骨疏灵颗粒的开发研制提供了实验依据。Objective To evaluate the effect of the excipients on hygroscopicity of Gushuling Granules and optimize the damp-proof excipients. Methods Moisture absorption rate was used to optimize the type and ratio of materials; The concentration of ethanol, moisture absorption rate, formability, angle of repose, and appearance of Gushuling Granules were used to optimize the molding technology. Results The best damp-proofing excipients were as follows： the hybrid materials were lactose-mannitol 4： 1, medicine-auxiliary ratio of 1 ： 2, and with 85% ethanol to granulate. Gushuling Granules were good uniform, damp-proofing, and formability, the critical relative humidity was 76%. Conclusion The preparation technology is stable. The study provides the experimental evidences for the research and development of Gushuling Granules.

关 键 词：骨疏灵颗粒 防潮辅料 吸湿性 成型性 乳糖 甘露醇 休止角 

分 类 号：R283.6[医药卫生—中药学]