Research Progress in Corneal Cross-linking Agents  

作　　者：Na Li Xiujun Peng Zhengjun Fan 

机构地区：[1]Chinese ,PLA Medical School & PLA General Hospital [2]Department of Ophthalmology, Navy General Hospital of Chinese PLA

出　　处：《Eye Science》2014年第2期125-128,共4页眼科学报（英文版）

摘　　要：Corneal collagen cross-linking with UVA-riboflavin is currently the only method for preventing the progression of keratoconus from the pathological perspective. Topical application of a direct cross-linking agent is now attracting widespread attention in clinical settings..This article reviews the research progress in the application of indirect or direct cross-linking agents(e.g., riboflavin, glucose, ribose, glutaraldehyde,formaldehyde,.glyceraldehyde,.short chain aliphatic β-nitro alcohol, and genipin) in the treatment of corneal diseases and analyzes the cross-linking efficacy,.toxicity,.and merits and disadvantages of each cross-linking agent,.providing clinical information for further studies.Corneal collagen cross-linking with UVA-riboflavin is currently the only method for preventing the progression of keratoconus from the pathological perspective. Topical application of a direct cross-linking agent is now attracting widespread attention in clinical settings. This article reviews the research progress in the application of indirect or direct cross-linking agents （e.g., riboflavin, glucose, ribose, glutaraldehyde, formaldehyde, glyceraldehyde, short chain aliphatic β-nitro alcohol, and genipin） in the treatment of corneal diseases and analyzes the cross-linking efficacy, toxicity, and merits and disadvantages of each cross-linking agent, providing clinical information for further studies.

关 键 词：交联剂 角膜 临床资料 核黄素 病理学 葡萄糖 戊二醛 硝基醇 

分 类 号：R772.2[医药卫生—眼科]