淋巴细胞绝对计数及CA 125与非霍奇金淋巴瘤国际预后指数的关系  

Relationship Between Absolute Lymphocyte Count and Serum CA125 and International Prognostic Index and the Prognostic Analysis of Patients with Non-Hodgkin Lymphoma

作　　者：牛晓敏[1] 何慧清[1] 黎伟超[1] 李卫华[1] 许晓军[1] 

机构地区：[1]中山大学附属中山医院血液科,广东中山528403

出　　处：《临床医学工程》2014年第7期860-862,共3页Clinical Medicine & Engineering

摘　　要：目的本研究探计淋巴瘤患者外周淋巴细胞绝对计数（absolutelymphocytecount，ALC）及CAl25检测的临床意义及其与国际预后指数（intemationalprognosticindex，IPI）的关系。方法回顾性的分析127例非霍奇金淋巴瘤患者临床资料，对初诊时ALC、CAl25、IPI评分系统及疗效进行统计分析。结果中位随访23．1月（7．9—48．3月）总有效率（RR）为73．2％，完全缓解率（cR）为59．8％，总生存率（os）为55．1％。高ALC（aLc≥1．0×10VL）组和低ALC（aLc〈1．0×109／L）组R．R率为82．9％和61．4％（P=0．007），CR率为72．9％和43．9％（P=0．001），总生存率（os）为63．2％和30％（P=0．000）。高CA125组和CA125正常组RR率为40％和88．5％（P=0．000），CR率为20％和78．2％（P=0．000）．总生存率为31％和75％（P=0．000）。将IpI评分0～1分和2分合并为低危组，3分、4～5分合并为高危组，统计分析显示，高危组淋巴细胞绝对计数较低危组明显降低（P=0．020），高危组CA125水平高于低危组（P=O，000）。结论ALC及CA125可与IPI评分系统一起用于评价弥漫大B细胞淋巴瘤患者的预后。Objective This study aims to investigate the clinical significance and prognostic value of peripheral blood absolute lymphocyte count（ALC） and serum CA125 at patients with non-Hodgkin lymphoma. Methods A totle of 127 patients with non-Hodgkin lymphoma in our department of hematotogy fxom 2008-01 to 2013-01 were enrolled arid analyzed retrospectively. The correlation between different ALC level and serum CA125 and international prognostic index were statistically analyzed. Results At a median follow-up of 23.1 months, the overall response rate （RR）was 73.2% with 59.8% complete remission rate （CR） and 55.1% overall survival rate （OS）. Patients with high ALC （ ≥ 1.0 x 109/L） at diagnosis tended to have higher RR, CR and OS. Patients with low ALC （ 〈 1.0 x 109/L） at diagnosis had bad treatment effect. ALC level in IPI 3 - 5 groups decreased significantly as compared with those in IPI 0 - 2 groups （P = 0.020）. Serum levels of CA125 were significantly elevated in the group IPI score ≥2 （P = 0.000）. Conclusions Our data show that ALC and serum CA125 at diagnosis with IPI scores system can be used for evaluating the prognosis of non-Hodgkin lymphoma patients

关 键 词：淋巴细胞绝对数 CA125 淋巴瘤 国际预后指数 预后 

分 类 号：R733[医药卫生—肿瘤]