Synthesis, Characterization and Antiepileptic Activity of Some New N-Substituted Phthalimide Analogs  

作　　者：Omran N. R. Fhid Shaban E. A. Saad Talal H. Zeglam Asma Eswayah Tariq Elmoug Esra Alnnas Yousra Haroon Ahmed A. Eldep Abdelhamed Ebzabez 

机构地区：[1]Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli 218-21, Libya [2]Department of Pharmacology, Faculty of Pharmacy, University of Tripoli, Tripoli 218-21, Libya

出　　处：《Journal of Life Sciences》2014年第4期373-377,共5页生命科学（英文版）

摘　　要：The present study was designed to investigate the anticonvulsant effect of series phthalimides possessing an N-aromatic amines moiety substituted at position 2 （2-7）. The compounds synthesized using phthalic anhydride and various amines in reflux synthesizer. The chemical structures of the titled compound were confirmed by physical and spectra analysis. All the synthesized compounds were evaluated in vivo for antiepileptic activity by using standard experimental models. Compounds： 2-（3H-1, 2, 4-Triazole-3-y） isoindoline-1, 3-dione （2）, Ethyl-4（1, 3-dioxoisoindoline-2-yl） benzoate 3 and 2-（4-nitrophenyl） isoindoline-1,3dione （7） were found significantly （P 〈 0.01-0.00001） delayed the onset and antagonized picrotoxin-induced seizures.

关 键 词：PHTHALIMIDES anticonvulsant activity reflux synthesizer. 

分 类 号：TQ463[化学工程—制药化工] O625.632[理学—有机化学]