PHTHALIMIDES

作品数：13被引量：7H指数：2
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Photoredox Synthesis of Thio-Functionalized Cyclic Ethers Using N-Sulfenyl Phthalimides as a Thiyl-Radical Precursor被引量：1
《Chinese Journal of Chemistry》2023年第15期1823-1828,共6页Maojian Lu Rong-Bin Liang Can-Ming Zhu Qing-Xiao Tong Jian-Ji Zhong 
the National Natural Science Foundation of China(22171177,51973107);the Chemistry and Chemical Engineering Guangdong Laboratory(1922003);the Guangdong Major Project of Basic and Applied Basic Research(2019B030302009);the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme2019(GDUPS2019).
Comprehensive Summary A visible-light mediated exclusively regioselective synthesis of 2,2-disubstituted thio-functionalized tetrahydrofurans,tetrahydro-pyrans and oxepanes has been described through an operationally ...
关键词：Photoredox catalysis Cyclic ethers Thio-functionalization Thiyl radical Sulfenylating reagent N-Sulfenyl phthalimides Synthetic methods CYCLOADDITION Reaction mechanisms 
N-Acetylenethio phthalimides: Sequential linkage for compositional click reaction
《Chinese Chemical Letters》2023年第2期183-187,共5页Wen-Chao Gao Kai Feng Jun Tian Juan Zhang Hong-Hong Chang Xuefeng Jiang 
supported by the National Natural Science Foundation of China (Nos. 21901179 and 22125103);the Scientific Activities of Selected Returned Overseas Professionals of Shanxi Province (No. 20200002);the Natural Science Foundation of Shanxi Province (No. 202103021224067);the Research Project of Shanxi Scholarship Council (No. HGKY2019029)。
Click chemistry has become a useful tool for diverse molecular linkage and modification, and the development of new click strategy that enable reversibility and multifunctionality is of high demand for the multifuncti...
关键词：Diversity-oriented synthesis Compositional click Reversible linkage Iridium catalysis Hydrophobic tagging 
Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents被引量：3
《Acta Pharmaceutica Sinica B》2022年第12期4446-4457,共12页Chengliang Sun Yao Cheng Xiaojia Liu Gefei Wang Wenjian Min Xiao Wang Kai Yuan Yi Hou Jiaxing Li Haolin Zhang Haojie Dong Liping Wang Chenguang Lou Yanze Sun Xinmiao Yu Hongbin Deng Yibei Xiao Peng Yang 
This study was supported by the National Natural Science Foundation of China(82073701,31900687,81973366);Natural Science Foundation of Jiangsu Province(BK2019040713,China);the Project Program of State Key Laboratory of Natural Medicines,China Pharmaceutical University(SKLNMZZ202013,China);This study was also supported by Jiangsu Key Laboratory of Drug Design and Optimization,China Pharmaceutical University(No.2020KFKT-5,China);the“Double First-Class”University Project(CPU2018GF04,China),and CAMS Innovation Fund for Medical Sciences(2021-I2M-1-070);The X-ray data were collected at the Shanghai Synchrotron Radiation Facility(SSRF,China)BL19U beamline.
Programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1)have emerged as one of the most promising immune checkpoint targets for cancer immunotherapy.Despite the inherent advantages of small-molecule inhibit...
关键词：PD-1/PD-L1 Small-molecule inhibitor IMMUNOTHERAPY Co-crystal structure 
Samarium( II )-electrocatalyzed chemoselective reductive alkoxylation of phthalimides被引量：2
《Organic Chemistry Frontiers》2022年第5期1308-1314,共7页Yu-Feng Zhang Mohamed Mellah 
The unprecedented samarium electrocatalyzed reductive alkoxylation of phthalimides in a single step is presented.Under mild conditions,using electrogenerated Sm(II)with TMSCl(trimethyl chlorosilane),N-substituted 3-al...
关键词：catalyzed REDUCTIVE SUBSTITUTED 
Tunable System for Electrochemical Reduction of Ketones and Phthalimides被引量：2
《Chinese Journal of Chemistry》2021年第12期3297-3302,共6页Yaxin Wang Jianyou Zhao Tianjiao Qiao Jian Zhang Gong Chen 
We are grateful to the National Natural Science Foundation of China(No.22001128);the National Science Foundation of Jiangsu Province(No.BK20200847);the National Science Foundation of Nanjing University of Chinese Medicine(No.NZY22001128).
Herein,we report an efficient,tunable system for electrochemical reduction of ketones and phthalimides at room temperature without the need for stoichiometric external reductants.By utilizing NaN_(3) as the electrolyt...
关键词：ELECTROCHEMISTRY REDUCTION KETONES PHTHALIMIDES Radical reactions 
Synthesis,biochemical evaluation and computational simulations of new cytochrome bc1 complex inhibitors based on N-(4-aryloxyphenyl)phthalimides
《Chinese Chemical Letters》2018年第12期1897-1900,共4页Hua Cheng Yan Fu Qing Chang Ni Zhang Mengwei Bu Yan Niu Qiongyou Wu Cheng Chen Francis Verpoort 
supported by the National Natural Science Foundation of China(Nos.21502062,21272091 and 21472063);Hubei Provincial Department of Education(No.Q20102606);Xiangyang Science and Technology Bureau(No.2010GG1B33);Structural Biomedicine and Pharmacochemistry of Hubei University of Arts and Science;the support from the Russian Foundation for Basic Research(No.18-29-04047);the Tomsk Polytechnic University Competitiveness Enhancement Program grant(No.VIU-195/2018)
The cytochrome bc1complex(the bc1complex or complex Ⅲ) is an attractive target for the discovery of numerous pharmaceuticals and pesticides. In order to identify new lead structures for this target, a new series of m...
关键词：Cytochrome bc_1 complex Inhibitor N-(4-Aryloxyphenyl)phthalimide SYNTHESIS Biochemical evaluation Computational simulation 
Synthesis and Structural Analysis of Novel Norspermidine Derivatives
《International Journal of Organic Chemistry》2017年第2期106-139,共34页Bogumil Brycki Iwona Kowalczyk Justyna Werner Tomasz Pospieszny Anna Koziróg 
A series of new norspermidine derivatives, both nonionic and cationic, have been obtained. Structures of the synthesized compounds have been estab-lished by FTIR, 1H NMR, 13C NMR, 2D NMR, mass spectrometry and element...
关键词：Polyamines Norspermidine PHTHALIMIDES Quaternary Ammonium Salts Antimicrobial Activity FTIR ^(1)H NMR ^(13)C NMR 2D NMR MS 
Synthesis, Characterization and Antiepileptic Activity of Some New N-Substituted Phthalimide Analogs
《Journal of Life Sciences》2014年第4期373-377,共5页Omran N. R. Fhid Shaban E. A. Saad Talal H. Zeglam Asma Eswayah Tariq Elmoug Esra Alnnas Yousra Haroon Ahmed A. Eldep Abdelhamed Ebzabez 
The present study was designed to investigate the anticonvulsant effect of series phthalimides possessing an N-aromatic amines moiety substituted at position 2 （2-7）. The compounds synthesized using phthalic anhydri...
关键词：PHTHALIMIDES anticonvulsant activity reflux synthesizer. 
Water-Promoted Ring-Opening Reactions of N-Substituted Saccharins and Phthalimides by Amines
《Chinese Journal of Chemistry》2014年第9期871-877,共7页Lisha Bai Xuan Zhang Ning Ma 
We thank the National Natural Science Foundation of China(No.20802049)for financial support.
The reactions of N-substituted saccharins and phthalimides with amines were promoted by water.Various o-sulfamoyl benzamides and N,N′-disubstituted phthalamides were prepared in moderate to good yields.These reaction...
关键词：SULFONAMIDES HYDROLYSIS RING-OPENING saccharins PHTHALIMIDES 
The Synthesis of Arylsulfonylphthalimides and Their Reactions with Several Amines in Acetonitrile
《International Journal of Organic Chemistry》2011年第4期202-206,共5页Seyhan Ozturk Halil Kutuk 
In this study, several N-(p-substituted-arylsulfonyl)phthalimides (1a-e) were synthesized. The synthesized compounds were then examined with respect to their substitution reactions with t-butylamine, diethylamine, cyc...
关键词：Arylsulfonyl PHTHALIMIDES Mechanism SUBSTITUENT Effect Activation Entropy 
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