吉非替尼联合鸦胆子油乳剂治疗晚期非小细胞肺癌的疗效  

To explore the effect of Gefitinib and Brucea javanica oil emulsion(BJOE)for Advanced Non-small Cell Lung Cancer

作　　者：曹玉娟[1] 王德林[1] 刘承伟[1] 杜芳[1] 郝龙英[1] 曹凤[1] 李伟伟[1] 赵聪[1] 

机构地区：[1]北京大学首钢医院,北京石景山100144

出　　处：《中医临床研究》2014年第3期146-148,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:本研究探讨吉非替尼联合鸦胆子油乳二线对晚期NSCLC的疗效的影响。方法:将58例晚期NSCLC随机分为两组,每组29例,所有研究对象均给予吉非替尼,治疗组在对照组的基础上加用鸦胆子油乳,所有患者每月随访复查一次,比较两组的临床疗效和安全性以及生存资料的资料。结果:治疗组的临床疗效疾病控制率为79.3%,明显优于对照组58.6%,两组差异有统计学意义(P<0.05);治疗组疾病中位PFS为11个月;对照组的PFS为6个月;治疗组中位生存时间(MST)为17个月;对照组的MST为12个月;两组的不良反应是骨髓抑制及消化道反应,治疗组好于对照组;并能改善治疗组KSP评分,故和常规放化疗比较,不良反应程度较轻。结论:吉非替尼联合鸦胆子治疗老年晚期NSCLC患者,其疗效较好,能提高患者生存率,有明显的生存疗效;因其不良反应少,患者有较好的耐受性,故值得临床推广。objective：The aim of this study is to explore the effects and safety of Gefitinib and Brucea javanica oil emulsion （BJOE） on patients with advanced NSCLC . Methods：58 advanced NSCLC patients were randomly divided into two groups ,the contol group （n=29） and the treatment group（n=29）;All patients were given Gefitinib;the treatment group were given Brucea javanica oil emulsionas anti-tumor therapy as well. All the patients were followed monthly review once, compared two groups of clinical curative effect and security, and survival data information. Results：after treatment, the disease control rate of treatment group was 79.3%, is obviously better than that of the control group which was 58.6%.For the treatment groups, median survival time was 17 months,median progression-free survival （mPFS） was 11 months,In the control group, median survival time was 12 months, median progression-free survival （mPFS） was 6 months, there was a significandifference（P〈0.05）.And the most common adverse reactions were neutropenia and digestive tract reaction;improved the KFS score of the treatment group and the adverse reaction was lighter. Conclusion：the gefitinib and Brucea javanica oil emulsion were effective in treating advanced NSCLC,can improve dsurvival rate,reduce the level of tumor markers;because of few side effects and well tolerance,It is worth expanding the clinical usage of the preparation.

关 键 词：鸦胆子油乳剂 吉非替尼 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]