^(125)I放射性粒子植入在晚期肝癌治疗中的临床研究  

Clinical Study of ^(125)I Radioactive Seed Implantation in Treatment of Advanced Primary Liver Cancer

作　　者：刘东莲[1] 萨日娜[1] 白云飞[1] 

机构地区：[1]北京军区总医院263临床部消化道肿瘤中心,北京101149

出　　处：《解放军医药杂志》2014年第7期78-80,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨CT引导下125I放射性粒子植入治疗肝癌的疗效。方法回顾性分析2007年8月—2013年3月经125I放射性粒子植入治疗肝癌29例的临床资料,评价疗效、生存期、副作用及并发症情况。结果本组术后6、12、18、24个月缓解率分别为82.8%、75.9%、66.7%、68.0%。1、2年生存率100%、86.2%。术后3例出现肝功能损害,4例出现I度骨髓抑制,3例术后出现出血,给予对症治疗后均好转,无气胸发生。结论125I放射性粒子植入治疗肝癌疗效佳,生存期长,毒副反应少,可作为晚期原发性肝癌的有效治疗手段。Objective To explore the curative effect of CT-guided 125 I radioactive seed implantation in treatment of liver cancer. Methods Clinical data of 125 I radioactive seed implantation in treatment of 29 patients with liver cancer during Augest 2007 and March 2013 was retrospectively analyzed, and the curative effect, survival rate, side effects and complications were also evaluated. Results The remission rates 6th month, 12th months, 18th months and 24th months af-ter the operation were 82. 8℅ , 75. 9℅ , 66. 7℅ and 68. 0℅ respectively. Survival rates of one and two years were 100℅and 86. 2℅ . After the operation, 3 patients had impaired liver function, 4 patients had grade I myelosuppression, and 3 patients had postoperative bleeding, and all the patients improved after symptomatic treatment without pneumothorax. Conclusion 125 I radioactive seed implantation in treatment of liver cancer may achieve a good effect, longer life span and fewer less effects, so it can be used as an effective treatment method for advanced primary liver cancer.

关 键 词：癌 肝细胞 放射疗法 碘放射性同位素 

分 类 号：R735.7[医药卫生—肿瘤] R817.8[医药卫生—临床医学]