非小细胞肺癌Notch1和Jagged1表达及意义  

Expression and significance of Notch1 and Jagged1 in non-small cell lung carcinoma

作　　者：罗彬[1] 秦蓁[2] 王旭东[3] 

机构地区：[1]重庆医药高等专科学校临床医学系,重庆401331 [2]重庆市第九人民医院呼吸内科,重庆400700 [3]重庆市第九人民医院病理科,重庆400700

出　　处：《现代预防医学》2014年第15期2819-2821,2833,共4页Modern Preventive Medicine

摘　　要：目的探讨Notch1和Jagged1在非小细胞肺癌中的表达和临床病理学意义。方法应用免疫组化S-P方法,检测80例非小细胞肺癌组织Notch1和Jagged1的表达,分析其与非小细胞肺癌各临床病理学参数之间的关系。结果非小细胞肺癌Notch1和Jagged1表达显著高于癌旁正常肺组织(P<0.01)。Notch1和Jagged1在非小细胞肺癌的表达有淋巴结转移者显著高于无淋巴结转移者(P<0.05),非小细胞肺癌Notch1和Jagged1表达Ⅲ和Ⅳ期高于Ⅰ和Ⅱ期(分别P<0.01;P<0.05)。肺腺癌Jagged1表达显著高于肺鳞癌(P<0.05)。非小细胞肺癌Notch1和Jagged1的表达呈正相关(P<0.01)。结论 Notch1和Jagged1表达与非小细胞肺癌发生发展密切相关。Objective To explore the expression and elinicopathologieal significance of Notehl and Jagged1 in non-small cell lung carcinoma. Methods The expression of Notch1 and Jagged1 was detected in 80 non-small cell lung carcinoma tissues by immunohistoehemieal method. The relationship with all clinieopathological parameters was analyzed. Results The expression of Notch1 and Jagged1 in non-small cell lung carcinoma tissues was significantly higher than that in para-caneerous normal lung tissues （P〈0.01）. The expression of Notch1 and Jagged1 was significantly higher in non-small cell lung carcinomas with lymph node metastasis than in non-small cell lung carcinomas without lymph node metastasis （P〈0.05）. It was significantly higher in stage- Ⅲ and - Ⅳ tumors than in stage- Ⅰ and - Ⅱ tumors （P〈0.01; P〈0.05）. Adenocarcinoma of the lung had higher Jagged1 expression than squamous cell carcinoma of the lung （P〈0.05）. The expression of Notch1 was positively correlated with that of Jagged1 in non-small cell lung carcinomas （P〈0.01）. Conclusion The expression of Notch1 and Jagged1 is closely correlated with carcinogenesis and progression of non-small cell lung carcinoma.

关 键 词：肺肿瘤 NOTCH1 JAGGED1 

分 类 号：R181.33[医药卫生—流行病学]