转录抑制因子Snail在口腔鳞状细胞癌中的表达及其与临床病理特征及预后多因素的关系  

The investigation of the relationship between expression of Snail in oral squamous cell carcinoma and its clinical factors as pathological characteristics and tumor prognosis

作　　者：郑阳玉[1,2] 张涛 刘来奎[2] 张智弘[1] 

机构地区：[1]南京医科大学第一附属医院病理科,江苏南京210029 [2]南京医科大学口腔医学研究所,江苏南京210029 [3]无锡市惠山区人民医院口腔科,江苏无锡214187

出　　处：《口腔医学》2014年第6期401-404,共4页Stomatology

基　　金：国家自然科学基金资助项目(81272968)

摘　　要：目的研究转录抑制因子Snail在口腔鳞状细胞癌(以下简称口腔鳞癌)中的表达及其与多种临床病理因素之间的关系,探讨其在口腔鳞癌治疗及预后评估中的意义。方法采用免疫组织化学染色半定量的方法检测83例术前未接受放、化疗或其他特殊治疗的原发性口腔鳞癌患者标本中Snail的表达情况,并对其与口腔鳞癌患者的临床病理因素、转移及预后之间的关系进行统计学分析。结果 83例口腔鳞癌组织标本中,Snail的表达率为89.2%,其中,高表达率为49.4%,低表达率为39.8%。口腔鳞癌组织中Snail的表达水平与患者的性别、年龄、肿瘤分化程度、肿瘤大小、临床分期及淋巴结转移之间在统计学上无显著性差异(P>0.05)。Snail表达水平与口腔鳞癌患者的复发之间有显著性差异(P=0.003)。结论口腔鳞癌患者癌组织中Snail的高表达与肿瘤复发及预后之间有一定相关关系。因此,Snail有可能作为口腔鳞癌患者复发和预后的预测指标。Objective To investigate the expression of Snail in oral squamous cell carecinoma （OSCC） and it＇s correlation with clinic opathologic parameters,in order to investigate its meaning in OSCC treatment and tumor prognosis,and to find biological marker for estimating OSCC recurrence,metastasis and prognosis. Methods Samples from 83 patients with OSCC were studied with semiquan- titative immunohistochemistry method. The expression of Snail was examined,and it was combined with clinicopathologic parameter to analyze recurrence rate after operation and mortality rate and prognosis. Results Our study showed that the expression of Snail was negative in normal epithelial tissue while the high expression of Snail was observed in 89% patients with OSCC in the nucleus or cyto- plasmic. The expression of Snail was not observed in only 11% patients. There were no statistically significant differences between the expression levels of Snail in the tumor of OSCC and sex, age, histological differentiation,tumor size, clinical stage, or lymph node metastasis（ P 〉 0.05 ）. There was a statistically significant increase in the expression levels of Snail with recurrence （ P = 0. 003 ）. Conclusions This study has found the close relationship between high expression of Snail in oral carcinoma and the recurrence and prognosis. High expression of Snail may provide a useful prognostic marker in OSCC patients.

关 键 词：SNAIL 口腔鳞状细胞癌 免疫组织化学 

分 类 号：R781.5[医药卫生—口腔医学]